Bioactive Sambong oil-loaded electrospun cellulose acetate nanofibers: Preparation, characterization, and in-vitro biocompatibility

Blumea balsamifera oil loaded cellulose acetate nanofiber mats were prepared by electrospinning. The inclusion of blumea oil increased the nanofiber diameter. FTIR spectra confirm the addition of blumea oil in the nanofiber mats. The XRD pattern suggests that the inclusion of blumea oil has caused a misalignment in the polymer chains of the cellulose acetate. Thus, a decrease in the tensile strength was observed for the blumea oil loaded nanofibers. The increase in fiber diameter causes a reduction in the porosity of the nanofiber mats. The blumea oil loaded nanofiber mats showed antibacterial efficacy against Escherichia coli and Staphylococcus aureus. The blumea oil showed antioxidant abilities against the DPPH solution. MVTR of the neat and blumea oil loaded nanofiber mats was in the range of 2450–1750 g/m²/day, which is adequate for the transport of air and moisture from the wound surface. Blumea oil loaded mats showed good cell viability ~92% for NIH 3T3 cells in more extended periods of incubation. A biphasic release profile was obtained, and the release followed the first-order kinetics depending upon the highest value of the coefficient of correlation R 2 (88.6%).