Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases

Bo Yuan, Abigail Page, Christopher P. Worrall, Franck Escalettes, Simon C. Willies, Joseph J W McDouall, Nicholas J. Turner, Jonathan Clayden

    Research output: Contribution to journalArticlepeer-review

    Abstract

    All roads lead to ⋯ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically enriched form by desymmetrizing atroposelective enzymatic oxidation (with a galactose oxidase (GOase) variant) or reduction (with a ketoreductase (KRED); see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)7010-7013
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Volume49
    Issue number39
    DOIs
    Publication statusPublished - 17 Sept 2010

    Keywords

    • Asymmetric synthesis atropisomerism biocatalysis diaryl ethers enzymes

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