Abstract
All roads lead to ⋯ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically enriched form by desymmetrizing atroposelective enzymatic oxidation (with a galactose oxidase (GOase) variant) or reduction (with a ketoreductase (KRED); see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Original language | English |
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Pages (from-to) | 7010-7013 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 39 |
DOIs | |
Publication status | Published - 17 Sept 2010 |
Keywords
- Asymmetric synthesis atropisomerism biocatalysis diaryl ethers enzymes
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CCDC 764850: Experimental Crystal Structure Determination
Yuan, B. (Contributor), Page, A. (Contributor), Worrall, C. P. (Contributor), Escalettes, F. (Contributor), Willies, S. C. (Contributor), Mcdouall, J. (Contributor), Turner, N. (Contributor) & Clayden, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2010
DOI: 10.5517/cctnwlx, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctnwlx&sid=DataCite
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