Biocompatible propulsion for biomedical micro/nano robotics

Micro/Nano robots have shown enormous potential for diverse biomedical applications, such as targeted delivery, in vivo biosensing, minimally invasive surgery and cell manipulation through extending their area of operation to various previously inaccessible locations. The motion of these small-scale robots can be either self–propelled or remotely controlled by some external power sources. However, in order to use them for biomedical applications, optimization of biocompatible propulsion and precise controllability are highly desirable. In this article, the recent progress about the biocompatible propulsion (e.g. self-propulsion, external stimuli based propulsion and bio-hybrid propulsion)techniques for these micro/nano robotic devices are summarized along with their applications, with a special focus on the advantages and disadvantages of different propulsion techniques. The current challenges and future perspectives of these small-scale devices are discussed in the final section.