Biogenesis of the sorting endosome: The role of Rab5

Philip G. Woodman

doi:10.1034/j.1600-0854.2000.010902.x

Biogenesis of the sorting endosome: The role of Rab5

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Abstract

Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5-interacting proteins and components of the membrane fusion apparatus. In addition, a realisation that Rab5 has additional functions in endosome biogenesis is emerging. These advances may be profoundly important in changing the way that we view the sorting endosome and in developing models that properly reflect the dynamic qualities of the endocytic pathway. Copyright © Munksgaard 2000.

Original language	English
Pages (from-to)	695-701
Number of pages	6
Journal	Traffic (Malden): the international journal of intracellular transport
Volume	1
Issue number	9
DOIs	https://doi.org/10.1034/j.1600-0854.2000.010902.x
Publication status	Published - 2000

Keywords

Fusion
FYVE
Membrane transport
PI(3)P
SNARE

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abstract = "Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5-interacting proteins and components of the membrane fusion apparatus. In addition, a realisation that Rab5 has additional functions in endosome biogenesis is emerging. These advances may be profoundly important in changing the way that we view the sorting endosome and in developing models that properly reflect the dynamic qualities of the endocytic pathway. Copyright {\textcopyright} Munksgaard 2000.",

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KW - Fusion

KW - FYVE

KW - Membrane transport

KW - PI(3)P

KW - SNARE

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DO - 10.1034/j.1600-0854.2000.010902.x

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JO - Traffic (Malden): the international journal of intracellular transport

JF - Traffic (Malden): the international journal of intracellular transport

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ER -

Biogenesis of the sorting endosome: The role of Rab5

Abstract

Keywords

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