Bioinformatics approaches for the classification of G-protein-coupled receptors

Anna Gaulton, Teresa K. Attwood

    Research output: Contribution to journalArticlepeer-review


    G-protein-coupled receptors are found abundantly in the human genome, and are the targets of numerous prescribed drugs. However, many receptors remain orphaned (i.e. with unknown ligand specificity), and others remain poorly characterised, with little structural information available. Consequently, there is often a gulf between sequence data and structural and functional knowledge of a receptor. Bioinformatics approaches may offer one approach to bridging this gap. In particular, protein family databases, which distil information from multiple sequence alignments into characteristic signatures, could be used to identify the families to which orphan receptors belong, and might facilitate discovery of novel motifs associated with ligand binding and G-protein-coupling.
    Original languageEnglish
    Pages (from-to)114-120
    Number of pages6
    JournalCurrent opinion in pharmacology
    Issue number2
    Publication statusPublished - Apr 2003


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