Bioinspired Intervertebral Disc with Multidirectional Stiffness Prepared via Multimaterial Additive Manufacturing

Guangsheng Song, Zhihui Qian, Xiangyu Liu, Boya Chen, Guanghui Li, Zhenguo Wang, Kunyang Wang, Zhenmin Zou, Fabio Galbusera, Marco Domingos, Lei Ren, Hans‐joachim Wilke, Luquan Ren

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Degenerative disc disease (DDD) has become a significant public health issue worldwide. This can result in loss of spinal function affecting patient health and quality of life. Artificial total disc replacement (A-TDR) is an effective approach for treating symptomatic DDD that compensates for lost functionality and helps patients perform daily activities. However, because current A-TDR devices lack the unique structure and material characteristics of natural intervertebral discs (IVDs), they fail to replicate the multidirectional stiffness needed to match physiological motions and characterize anisotropic behavior. It is still unclear how the multidirectional stiffness of the disc is affected by structural parameters and material characteristics. Herein, a bioinspired intervertebral disc (BIVD-L) based on a representative human lumbar segment is developed. The proposed BIVD-L reproduces the multidirectional stiffness needed for the most common physiological kinematic behaviors. The results demonstrate that the multidirectional stiffness of the BIVD-L can be regulated by structural and material parameters. The results of this research deepen knowledge of the biomechanical behavior of the human lumbar disc and may provide new inspirations for the design and fabrication of A-TDR devices for both engineering and functional applications.
Original languageEnglish
JournalAdvanced Functional Materials
Publication statusPublished - 3 Jul 2023


  • additive manufacturing
  • artificial total disc replacement
  • bioinspired designs
  • multidirectional stiffness
  • multimaterials


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