Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

D Doria; KF Kakolee; S Kar; SK Litt; F Fiorini; H Ahmed; S Green; JCJ Jeynes; J Kavanagh; D Kirby; KJ Kirkby; MJ Merchant; G Nersisyan; R Prasad; KM Prise; G Schettino; M Zepf; M Borghesi

doi:10.1063/1.3699063

Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

D Doria, KF Kakolee, S Kar, SK Litt, F Fiorini, H Ahmed, S Green, JCJ Jeynes, J Kavanagh, D Kirby, KJ Kirkby, MJ Merchant, G Nersisyan, R Prasad, KM Prise, G Schettino, M Zepf, M Borghesi

Research output: Contribution to journal › Article › peer-review

Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen???s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225kKVp X-ray source.

Original language	English
Pages (from-to)	011209-011215
Number of pages	7
Journal	AIP Advances
Volume	2
Issue number	1
DOIs	https://doi.org/10.1063/1.3699063
Publication status	Published - 22 Mar 2012

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Doria, D., Kakolee, KF., Kar, S., Litt, SK., Fiorini, F., Ahmed, H., Green, S., Jeynes, JCJ., Kavanagh, J., Kirby, D., Kirkby, KJ., Merchant, MJ., Nersisyan, G., Prasad, R., Prise, KM., Schettino, G., Zepf, M., & Borghesi, M. (2012). Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s. AIP Advances, 2(1), 011209-011215. https://doi.org/10.1063/1.3699063

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title = "Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s",

abstract = "The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen???s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225kKVp X-ray source.",

author = "D Doria and KF Kakolee and S Kar and SK Litt and F Fiorini and H Ahmed and S Green and JCJ Jeynes and J Kavanagh and D Kirby and KJ Kirkby and MJ Merchant and G Nersisyan and R Prasad and KM Prise and G Schettino and M Zepf and M Borghesi",

year = "2012",

month = mar,

day = "22",

doi = "10.1063/1.3699063",

language = "English",

volume = "2",

pages = "011209--011215",

journal = "AIP Advances",

issn = "2158-3226",

publisher = "American Institute of Physics",

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Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JCJ, Kavanagh, J, Kirby, D, Kirkby, KJ, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M & Borghesi, M 2012, 'Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s', AIP Advances, vol. 2, no. 1, pp. 011209-011215. https://doi.org/10.1063/1.3699063

TY - JOUR

T1 - Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

AU - Doria, D

AU - Kakolee, KF

AU - Kar, S

AU - Litt, SK

AU - Fiorini, F

AU - Ahmed, H

AU - Green, S

AU - Jeynes, JCJ

AU - Kavanagh, J

AU - Kirby, D

AU - Kirkby, KJ

AU - Merchant, MJ

AU - Nersisyan, G

AU - Prasad, R

AU - Prise, KM

AU - Schettino, G

AU - Zepf, M

AU - Borghesi, M

PY - 2012/3/22

Y1 - 2012/3/22

N2 - The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen???s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225kKVp X-ray source.

AB - The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen???s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225kKVp X-ray source.

U2 - 10.1063/1.3699063

DO - 10.1063/1.3699063

M3 - Article

SN - 2158-3226

VL - 2

SP - 11209

EP - 11215

JO - AIP Advances

JF - AIP Advances

IS - 1

ER -

Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

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