Biological phenotypes of heart failure with preserved ejection fraction

Gavin Lewis, Erik B Schelbert, Simon G Williams, Colin Cunnington, Fozia Ahmed, Theresa McDonagh, Christopher Miller

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Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials. A greater understanding of the in vivo human processes involved, and in particular, which are the causes and which are the downstream effects, may allow the syndrome of HFpEF to be distilled into distinct diagnoses based on the underlying biology. From this, specific interventions can follow, targeting individuals identified on the basis of their biological phenotype. This review describes the biological phenotypes of HFpEF and therapeutic interventions aimed at targeting these phenotypes.
Original languageEnglish
Pages (from-to)2186-2200
Number of pages15
JournalJournal of the American College of Cardiology
Issue number17
Early online date16 Oct 2017
Publication statusPublished - Oct 2017


  • heart failure with preserved ejection fraction
  • Heart failure
  • Diastolic dysfunction
  • Myocardial fibrosis
  • Ejection fraction


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