Biomimetic Presentation of Cryptic Ligands via Single-Chain Nanogels for Synergistic Regulation of Stem Cells

Xiaoyu Chen, Nathanael Chun-Him Lai, Kongchang Wei, Rui Li, Miao Cui, Boguang Yang, Siu Hong Dexter Wong, Yingrui Deng, Jiashen Li, Xintao Shuai, Liming Bian (Corresponding)

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Abstract

Dynamic controlling the nanoscale presentation of synergistic ligands to stem cells by biomimetic single-chain materials can provide critical insights to understand the molecular crosstalk underlying cells and their extracellular matrix. Here, a stimuli-responsive single-chain macromolecular nano-regulator with conformational dynamics is fabricated based on advanced scale-up single polymeric chain nanogel (SCNG). Such carefully-designed SCNG is capable of mediating triggered co-presentation of the master and cryptic ligands in a single molecule to elicit the synergistic crosstalk between different intracellular signaling pathways, thereby considerably boosting the bioactivity of the presented ligands. This controllable nanoswitching-on of cell‐adhesive ligands' presentation allows regulation of cell adhesion and fate from molecular scale. The modular nature of this synthetic macromolecular nano-regulator makes it a versatile nanomaterial platform to assist basic and fundamental studies in a wide array of research topics.
Original languageEnglish
JournalACS Nano
Early online date30 Mar 2020
DOIs
Publication statusE-pub ahead of print - 30 Mar 2020

Keywords

  • single-chain nanogel
  • stem cells regulation
  • cryptic ligands presentation
  • stimuli-responsive nano-regulator
  • synergistic ligands

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