Biomimicry 1: PC.

D C Cumberland; J Gunn; N Malik; C M Holt

Biomimicry 1: PC.

D C Cumberland, J Gunn, N Malik, C M Holt

Research output: Contribution to journal › Article › peer-review

Abstract

The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.

Original language	English
Journal	Seminars in interventional cardiology : SIIC
Volume	3
Issue number	3-4
Publication status	Published - 1998

Cite this

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title = "Biomimicry 1: PC.",

abstract = "The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.",

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year = "1998",

language = "English",

volume = "3",

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issn = "1084-2764",

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T1 - Biomimicry 1: PC.

AU - Cumberland, D C

AU - Gunn, J

AU - Malik, N

AU - Holt, C M

PY - 1998

Y1 - 1998

N2 - The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.

AB - The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.

M3 - Article

C2 - 10406685

SN - 1084-2764

VL - 3

JO - Seminars in interventional cardiology : SIIC

JF - Seminars in interventional cardiology : SIIC

IS - 3-4

ER -

Biomimicry 1: PC.

Abstract

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