Bioresponsive hydrogels

R V Ulijn, N Bibi, V Jayawarna, P D Thornton, S J Todd, R J Mart, A M Smith, J E Gough

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We highlight recent developments in hydrogel materials with biological responsiveness built in. These 'smart' biomaterials change properties in response to selective biological recognition events. When exposed to a biological target (nutrient, growth factor, receptor, antibody, enzyme, or whole cell), molecular recognition events trigger changes in molecular interactions that translate into macroscopic responses, such as swelling/collapse or solution-to-gel transitions. The hydrogel transitions may be used directly as optical readouts for biosensing, linked to the release of actives for drug delivery, or instigate biochemical signaling events that control or direct cellular behavior. Accordingly, bioresponsive hydrogels have gained significant interest for application in diagnostics, drug delivery, and tissue regeneration/wound healing.
    Original languageEnglish
    Pages (from-to)40-48
    Number of pages9
    JournalMaterials Today
    Volume10
    Issue number4
    Publication statusPublished - Apr 2007

    Keywords

    • PHOTONIC CRYSTAL
    • SUPRAMOLECULAR HYDROGEL
    • RESPONSIVE POLYMERS
    • SENSITIVE HYDROGELS
    • CELL-MIGRATION
    • DRUG-DELIVERY
    • IN-VIVO
    • BIOMATERIALS
    • GLUCOSE
    • MEDICINE

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