Biotransformations in low-boiling hydrofluorocarbon solvents

Simon Saul; Stuart Corr; Jason Micklefield

doi:10.1002/anie.200460082

Biotransformations in low-boiling hydrofluorocarbon solvents

Simon Saul, Stuart Corr, Jason Micklefield

Research output: Contribution to journal › Article › peer-review

Abstract

Solvent solutions: Low-boiling hydrofluorocarbons (see examples) are excellent solvents for lipase-catalyzed reactions and ideal replacements for conventional organic solvents and supercritical fluids as media for nonaqueous biotransformations. Notably increased rates, yields, and enantioselectivities were observed with the model kinetic resolution of (±)-1-phenylethanol and the desymmetrization of weso-2-cyclopentene-1 ,4-diol.

Original language	English
Pages (from-to)	5519-5523
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	41
DOIs	https://doi.org/10.1002/anie.200460082
Publication status	Published - 18 Oct 2004

Keywords

Biotransformations
Desymmetrization
Hydrofluorocarbons
Kinetic resolution
Lipases

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10.1002/anie.200460082

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abstract = "Solvent solutions: Low-boiling hydrofluorocarbons (see examples) are excellent solvents for lipase-catalyzed reactions and ideal replacements for conventional organic solvents and supercritical fluids as media for nonaqueous biotransformations. Notably increased rates, yields, and enantioselectivities were observed with the model kinetic resolution of (±)-1-phenylethanol and the desymmetrization of weso-2-cyclopentene-1 ,4-diol.",

keywords = "Biotransformations, Desymmetrization, Hydrofluorocarbons, Kinetic resolution, Lipases",

author = "Simon Saul and Stuart Corr and Jason Micklefield",

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AU - Corr, Stuart

AU - Micklefield, Jason

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N2 - Solvent solutions: Low-boiling hydrofluorocarbons (see examples) are excellent solvents for lipase-catalyzed reactions and ideal replacements for conventional organic solvents and supercritical fluids as media for nonaqueous biotransformations. Notably increased rates, yields, and enantioselectivities were observed with the model kinetic resolution of (±)-1-phenylethanol and the desymmetrization of weso-2-cyclopentene-1 ,4-diol.

AB - Solvent solutions: Low-boiling hydrofluorocarbons (see examples) are excellent solvents for lipase-catalyzed reactions and ideal replacements for conventional organic solvents and supercritical fluids as media for nonaqueous biotransformations. Notably increased rates, yields, and enantioselectivities were observed with the model kinetic resolution of (±)-1-phenylethanol and the desymmetrization of weso-2-cyclopentene-1 ,4-diol.

KW - Biotransformations

KW - Desymmetrization

KW - Hydrofluorocarbons

KW - Kinetic resolution

KW - Lipases

U2 - 10.1002/anie.200460082

DO - 10.1002/anie.200460082

M3 - Article

SN - 1433-7851

VL - 43

SP - 5519

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 41

ER -

Biotransformations in low-boiling hydrofluorocarbon solvents

Abstract

Keywords

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