Biotransformations in low-boiling hydrofluorocarbon solvents

Simon Saul, Stuart Corr, Jason Micklefield

    Research output: Contribution to journalArticlepeer-review


    Solvent solutions: Low-boiling hydrofluorocarbons (see examples) are excellent solvents for lipase-catalyzed reactions and ideal replacements for conventional organic solvents and supercritical fluids as media for nonaqueous biotransformations. Notably increased rates, yields, and enantioselectivities were observed with the model kinetic resolution of (±)-1-phenylethanol and the desymmetrization of weso-2-cyclopentene-1 ,4-diol.
    Original languageEnglish
    Pages (from-to)5519-5523
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Issue number41
    Publication statusPublished - 18 Oct 2004


    • Biotransformations
    • Desymmetrization
    • Hydrofluorocarbons
    • Kinetic resolution
    • Lipases


    Dive into the research topics of 'Biotransformations in low-boiling hydrofluorocarbon solvents'. Together they form a unique fingerprint.

    Cite this