Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease

Viggo Jønsson; Geir Tjønnfjord; Sven Ove Samuelsen; Tom Johannesen; Jørgen Olsen; Gabrielle Sellick; Richard Houlston; Martin Yuille; Daniel Catovsky

doi:10.1080/10428190701686273

Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease

Viggo Jønsson, Geir Tjønnfjord, Sven Ove Samuelsen, Tom Johannesen, Jørgen Olsen, Gabrielle Sellick, Richard Houlston, Martin Yuille, Daniel Catovsky

Research output: Contribution to journal › Article › peer-review

Abstract

Rank order of affected offspring in a sibship can inform on epigenetic factors in disease susceptibility. Here we report an analysis of birth order in 32 families segregating chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative disorders. A paternal-offspring, but not a maternal-offspring birth rank order was observed. Cox regression analysis provided relative risks (RR) for paternal and maternal transmission of 3.60 (CI 95%: 1.54-8.42; P=0.0005) and 1.64 (CI 95%: 0.90-3.01; P=0.096), respectively. The significance of paternal and maternal transmission of CLL-CLL pairs employing Haldane and Smith's test were 0.006 and 0.63, respectively. There was no evidence of a relationship between parental age and birth order. The genetic mechanism behind the birth order effect observed is discussed in the light of non-Mendelian imprinting and pregnancy related microchimerism.

Original language	English
Pages (from-to)	2387-2396
Number of pages	9
Journal	Leukemia and Lymphoma
Volume	48
Issue number	12
DOIs	https://doi.org/10.1080/10428190701686273
Publication status	Published - Dec 2007

Keywords

Birth-order effect
Chronic lymphocytic leukaemia
Imprinting
Lymphoproliferative disorders
Microchimerism
Non-Hodgkin's lymphoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease",

abstract = "Rank order of affected offspring in a sibship can inform on epigenetic factors in disease susceptibility. Here we report an analysis of birth order in 32 families segregating chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative disorders. A paternal-offspring, but not a maternal-offspring birth rank order was observed. Cox regression analysis provided relative risks (RR) for paternal and maternal transmission of 3.60 (CI 95%: 1.54-8.42; P=0.0005) and 1.64 (CI 95%: 0.90-3.01; P=0.096), respectively. The significance of paternal and maternal transmission of CLL-CLL pairs employing Haldane and Smith's test were 0.006 and 0.63, respectively. There was no evidence of a relationship between parental age and birth order. The genetic mechanism behind the birth order effect observed is discussed in the light of non-Mendelian imprinting and pregnancy related microchimerism.",

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T1 - Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease

AU - Jønsson, Viggo

AU - Tjønnfjord, Geir

AU - Samuelsen, Sven Ove

AU - Johannesen, Tom

AU - Olsen, Jørgen

AU - Sellick, Gabrielle

AU - Houlston, Richard

AU - Yuille, Martin

AU - Catovsky, Daniel

N1 - DA - 20071210IS - 1042-8194 (Print)LA - engPT - Journal ArticleSB - IM

PY - 2007/12

Y1 - 2007/12

N2 - Rank order of affected offspring in a sibship can inform on epigenetic factors in disease susceptibility. Here we report an analysis of birth order in 32 families segregating chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative disorders. A paternal-offspring, but not a maternal-offspring birth rank order was observed. Cox regression analysis provided relative risks (RR) for paternal and maternal transmission of 3.60 (CI 95%: 1.54-8.42; P=0.0005) and 1.64 (CI 95%: 0.90-3.01; P=0.096), respectively. The significance of paternal and maternal transmission of CLL-CLL pairs employing Haldane and Smith's test were 0.006 and 0.63, respectively. There was no evidence of a relationship between parental age and birth order. The genetic mechanism behind the birth order effect observed is discussed in the light of non-Mendelian imprinting and pregnancy related microchimerism.

AB - Rank order of affected offspring in a sibship can inform on epigenetic factors in disease susceptibility. Here we report an analysis of birth order in 32 families segregating chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative disorders. A paternal-offspring, but not a maternal-offspring birth rank order was observed. Cox regression analysis provided relative risks (RR) for paternal and maternal transmission of 3.60 (CI 95%: 1.54-8.42; P=0.0005) and 1.64 (CI 95%: 0.90-3.01; P=0.096), respectively. The significance of paternal and maternal transmission of CLL-CLL pairs employing Haldane and Smith's test were 0.006 and 0.63, respectively. There was no evidence of a relationship between parental age and birth order. The genetic mechanism behind the birth order effect observed is discussed in the light of non-Mendelian imprinting and pregnancy related microchimerism.

KW - Birth-order effect

KW - Chronic lymphocytic leukaemia

KW - Imprinting

KW - Lymphoproliferative disorders

KW - Microchimerism

KW - Non-Hodgkin's lymphoma

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DO - 10.1080/10428190701686273

M3 - Article

SN - 1042-8194

VL - 48

SP - 2387

EP - 2396

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 12

ER -

Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease

Abstract

Keywords

UN SDGs

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