Blockable Zn10L15 Ion Channels through Subcomponent Self‐Assembly

Call J. E.  Haynes; Jinbo Zhu; Catalin Chimerel; Silvia Hernandez-Ainsa; Imogen Riddell; Tanya K. Ronson; Ulrich F. Keyser; Jonathan R. Nitschke

doi:10.1002/anie.201709544

Blockable Zn10L15 Ion Channels through Subcomponent Self‐Assembly

Call J. E. Haynes (Lead), Jinbo Zhu (Lead), Catalin Chimerel, Silvia Hernandez-Ainsa, Imogen Riddell, Tanya K. Ronson, Ulrich F. Keyser (Corresponding), Jonathan R. Nitschke (Corresponding)

Research output: Contribution to journal › Letter › peer-review

Abstract

Metal–organic anion channels based on Zn10L15 pentagonal prisms have been prepared by subcomponent self-assembly. The insertion of these prisms into lipid membranes was investigated by ion-current and fluorescence measurements. The channels were found to mediate the transport of Cl− anions through planar lipid bilayers and into vesicles. Tosylate anions were observed to bind and plug the central channels of the prisms in the solid state and in solution. In membranes, dodecyl sulfate blocked chloride transport through the central channel. Our Zn10L15 prism thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through addition of the blocker dodecyl sulfate.

Original language	English
Pages (from-to)	15590-15594
Journal	Angewandte Chemie - International Edition
Volume	129
Issue number	48
DOIs	https://doi.org/10.1002/anie.201709544
Publication status	Published - 2017

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10.1002/anie.201709544

CCDC 1540884: Experimental Crystal Structure Determination
Haynes, C. J. E. (Contributor), Zhu, J. (Contributor), Chimerel, C. (Contributor), Hernandez-Ainsa, S. (Contributor), Riddell, I. (Contributor), Ronson, T. K. (Contributor), Keyser, U. F. (Contributor) & Nitschke, J. R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2017
DOI: 10.5517/ccdc.csd.cc1nqdyq, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1nqdyq&sid=DataCite
Dataset

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@article{2431f884b6da469999c1e60f3432540e,

title = "Blockable Zn10L15 Ion Channels through Subcomponent Self‐Assembly",

abstract = "Metal–organic anion channels based on Zn10L15 pentagonal prisms have been prepared by subcomponent self-assembly. The insertion of these prisms into lipid membranes was investigated by ion-current and fluorescence measurements. The channels were found to mediate the transport of Cl− anions through planar lipid bilayers and into vesicles. Tosylate anions were observed to bind and plug the central channels of the prisms in the solid state and in solution. In membranes, dodecyl sulfate blocked chloride transport through the central channel. Our Zn10L15 prism thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through addition of the blocker dodecyl sulfate.",

author = "Haynes, {Call J. E.} and Jinbo Zhu and Catalin Chimerel and Silvia Hernandez-Ainsa and Imogen Riddell and Ronson, {Tanya K.} and Keyser, {Ulrich F.} and Nitschke, {Jonathan R.}",

year = "2017",

doi = "10.1002/anie.201709544",

language = "English",

volume = "129",

pages = "15590--15594",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons Ltd",

number = "48",

}

TY - JOUR

T1 - Blockable Zn10L15 Ion Channels through Subcomponent Self‐Assembly

AU - Chimerel, Catalin

AU - Hernandez-Ainsa, Silvia

AU - Riddell, Imogen

AU - Ronson, Tanya K.

A2 - Haynes, Call J. E.

A2 - Zhu, Jinbo

A2 - Keyser, Ulrich F.

A2 - Nitschke, Jonathan R.

PY - 2017

Y1 - 2017

N2 - Metal–organic anion channels based on Zn10L15 pentagonal prisms have been prepared by subcomponent self-assembly. The insertion of these prisms into lipid membranes was investigated by ion-current and fluorescence measurements. The channels were found to mediate the transport of Cl− anions through planar lipid bilayers and into vesicles. Tosylate anions were observed to bind and plug the central channels of the prisms in the solid state and in solution. In membranes, dodecyl sulfate blocked chloride transport through the central channel. Our Zn10L15 prism thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through addition of the blocker dodecyl sulfate.

AB - Metal–organic anion channels based on Zn10L15 pentagonal prisms have been prepared by subcomponent self-assembly. The insertion of these prisms into lipid membranes was investigated by ion-current and fluorescence measurements. The channels were found to mediate the transport of Cl− anions through planar lipid bilayers and into vesicles. Tosylate anions were observed to bind and plug the central channels of the prisms in the solid state and in solution. In membranes, dodecyl sulfate blocked chloride transport through the central channel. Our Zn10L15 prism thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through addition of the blocker dodecyl sulfate.

U2 - 10.1002/anie.201709544

DO - 10.1002/anie.201709544

M3 - Letter

SN - 1433-7851

VL - 129

SP - 15590

EP - 15594

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 48

ER -

Blockable Zn10L15 Ion Channels through Subcomponent Self‐Assembly

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CCDC 1540884: Experimental Crystal Structure Determination

Cite this