Blockable Zn10L15 ion channels via subcomponent self-assembly

Call J. E. Haynes, Jinbo Zhu, Catalin Chimerel, Silvia Hernandez-Ainsa, Imogen Riddell, Tanya K. Ronson, Ulrich F. Keyser, Jonathan R. Nitschke

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    Metal–organic anion channels based on Zn10L15 pentagonal prisms have been prepared by subcomponent self-assembly. The insertion of these prisms into lipid membranes was investigated by ion-current and fluorescence measurements. The channels were found to mediate the transport of Cl anions through planar lipid bilayers and into vesicles. Tosylate anions were observed to bind and plug the central channels of the prisms in the solid state and in solution. In membranes, dodecyl sulfate blocked chloride transport through the central channel. Our Zn10L15 prism thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through addition of the blocker dodecyl sulfate.
    Original languageEnglish
    Pages (from-to)15388-15392
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Issue number48
    Early online date3 Nov 2017
    Publication statusPublished - 22 Nov 2017


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