Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

Andrew G. Renehan; Margaret Tyson; Matthias Egger; Richard F. Heller; Marcel Zwahlen

doi:10.1016/S0140-6736(08)60269-X

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

Andrew G. Renehan, Margaret Tyson, Matthias Egger, Richard F. Heller, Marcel Zwahlen

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Excess bodyweight, expressed as increased body-mass index (BMI), is associated with the risk of some common adult cancers. We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups. Methods: We did electronic searches on Medline and Embase (1966 to November 2007), and searched reports to identify prospective studies of incident cases of 20 cancer types. We did random-effects meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of cancer associated with a 5 kg/m2 increase in BMI. Findings: We analysed 221 datasets (141 articles), including 282 137 incident cases. In men, a 5 kg/m2 increase in BMI was strongly associated with oesophageal adenocarcinoma (RR 1·52, p

Original language	English
Pages (from-to)	569-578
Number of pages	9
Journal	The Lancet
Volume	371
Issue number	9612
DOIs	https://doi.org/10.1016/S0140-6736(08)60269-X
Publication status	Published - 2008

Keywords

Body Mass Index
Ethnic Groups
Female
Humans
Male
etiology: Neoplasms
complications: Overweight
Regression Analysis
Risk
Sex Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(08)60269-X

Cite this

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title = "Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies",

abstract = "Background: Excess bodyweight, expressed as increased body-mass index (BMI), is associated with the risk of some common adult cancers. We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups. Methods: We did electronic searches on Medline and Embase (1966 to November 2007), and searched reports to identify prospective studies of incident cases of 20 cancer types. We did random-effects meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of cancer associated with a 5 kg/m2 increase in BMI. Findings: We analysed 221 datasets (141 articles), including 282 137 incident cases. In men, a 5 kg/m2 increase in BMI was strongly associated with oesophageal adenocarcinoma (RR 1·52, p",

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author = "Renehan, {Andrew G.} and Margaret Tyson and Matthias Egger and Heller, {Richard F.} and Marcel Zwahlen",

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T1 - Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

AU - Renehan, Andrew G.

AU - Tyson, Margaret

AU - Egger, Matthias

AU - Heller, Richard F.

AU - Zwahlen, Marcel

PY - 2008

Y1 - 2008

N2 - Background: Excess bodyweight, expressed as increased body-mass index (BMI), is associated with the risk of some common adult cancers. We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups. Methods: We did electronic searches on Medline and Embase (1966 to November 2007), and searched reports to identify prospective studies of incident cases of 20 cancer types. We did random-effects meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of cancer associated with a 5 kg/m2 increase in BMI. Findings: We analysed 221 datasets (141 articles), including 282 137 incident cases. In men, a 5 kg/m2 increase in BMI was strongly associated with oesophageal adenocarcinoma (RR 1·52, p

AB - Background: Excess bodyweight, expressed as increased body-mass index (BMI), is associated with the risk of some common adult cancers. We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups. Methods: We did electronic searches on Medline and Embase (1966 to November 2007), and searched reports to identify prospective studies of incident cases of 20 cancer types. We did random-effects meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of cancer associated with a 5 kg/m2 increase in BMI. Findings: We analysed 221 datasets (141 articles), including 282 137 incident cases. In men, a 5 kg/m2 increase in BMI was strongly associated with oesophageal adenocarcinoma (RR 1·52, p

KW - Body Mass Index

KW - Ethnic Groups

KW - Female

KW - Humans

KW - Male

KW - etiology: Neoplasms

KW - complications: Overweight

KW - Regression Analysis

KW - Risk

KW - Sex Factors

U2 - 10.1016/S0140-6736(08)60269-X

DO - 10.1016/S0140-6736(08)60269-X

M3 - Article

SN - 0140-6736

VL - 371

SP - 569

EP - 578

JO - The Lancet

JF - The Lancet

IS - 9612

ER -

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

Abstract

Keywords

UN SDGs

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