Bone marrow innervation regulates cellular retention in the murine hematopoietic system

J. A. Miyan, A. M. Afan, S. Nichoils, A. D. Whetton, C. S. Broome

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Mechanisms for retention or mobilization of cells within the bone marrow that may involve the nervous system were studied. An anatomical analysis of the innervation of the mouse femur reveals intimate association of hematopoietic and stromal cells with nerve fibres. Mechanical denervation of the femur results in rapid mobilization of cells into the peripheral blood. Analysis of the type of cells mobilized revealed that progenitor cells are amongst those apparently released into the peripheral blood. In non- / splenectomised mice, these progenitor cells were quickly cleared from the circulation while in splenectomised mice there was a persistence of cells in the circulation.. Chemical sympathectomy with 6-hydroxydopamine reveals that bone marrow cellutarity can be markedly reduced without a change in bone marrow progenitor cell numbers, an observation that argues for selective control of mobilization by the nervous system. We conclude that the innervation is vital to maintenance of the blood-marrow interface, to control of peripheral blood cell numbers and to mobilization of colony forming cells into the periphery.
    Original languageEnglish
    Pages (from-to)1115
    JournalExperimental Hematology
    Volume24
    Issue number9
    Publication statusPublished - 1996

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