Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine

Catherine A. Cosgrove; Luiz R R Castello-Branco; Tracy Hussell; Amy Sexton; Rafaela Giemza; Richard Phillips; Andrew Williams; George E. Griffin; Gordon Dougan; David J M Lewis

doi:10.1128/IAI.74.4.2449-2452.2006

Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine

Catherine A. Cosgrove, Luiz R R Castello-Branco, Tracy Hussell, Amy Sexton, Rafaela Giemza, Richard Phillips, Andrew Williams, George E. Griffin, Gordon Dougan, David J M Lewis

Research output: Contribution to journal › Article › peer-review

Abstract

Oral immunization of healthy adults with 107 CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	2449-2452
Number of pages	3
Journal	Infection and immunity
Volume	74
Issue number	4
DOIs	https://doi.org/10.1128/IAI.74.4.2449-2452.2006
Publication status	Published - Apr 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/IAI.74.4.2449-2452.2006

Fingerprint

Dive into the research topics of 'Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine'. Together they form a unique fingerprint.

Cite this

Cosgrove, C. A., Castello-Branco, L. R. R., Hussell, T., Sexton, A., Giemza, R., Phillips, R., Williams, A., Griffin, G. E., Dougan, G., & Lewis, D. J. M. (2006). Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine. Infection and immunity, 74(4), 2449-2452. https://doi.org/10.1128/IAI.74.4.2449-2452.2006

@article{b19b04d4c9db44edba680feda2d60adb,

title = "Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine",

abstract = "Oral immunization of healthy adults with 107 CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines. Copyright {\textcopyright} 2006, American Society for Microbiology. All Rights Reserved.",

author = "Cosgrove, {Catherine A.} and Castello-Branco, {Luiz R R} and Tracy Hussell and Amy Sexton and Rafaela Giemza and Richard Phillips and Andrew Williams and Griffin, {George E.} and Gordon Dougan and Lewis, {David J M}",

note = "043139, Wellcome Trust, United Kingdom",

year = "2006",

month = apr,

doi = "10.1128/IAI.74.4.2449-2452.2006",

language = "English",

volume = "74",

pages = "2449--2452",

journal = "Infection and immunity",

issn = "1098-5522",

publisher = "American Society for Microbiology",

number = "4",

}

Cosgrove, CA, Castello-Branco, LRR, Hussell, T, Sexton, A, Giemza, R, Phillips, R, Williams, A, Griffin, GE, Dougan, G & Lewis, DJM 2006, 'Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine', Infection and immunity, vol. 74, no. 4, pp. 2449-2452. https://doi.org/10.1128/IAI.74.4.2449-2452.2006

Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine. / Cosgrove, Catherine A.; Castello-Branco, Luiz R R; Hussell, Tracy et al.
In: Infection and immunity, Vol. 74, No. 4, 04.2006, p. 2449-2452.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine

AU - Cosgrove, Catherine A.

AU - Castello-Branco, Luiz R R

AU - Hussell, Tracy

AU - Sexton, Amy

AU - Giemza, Rafaela

AU - Phillips, Richard

AU - Williams, Andrew

AU - Griffin, George E.

AU - Dougan, Gordon

AU - Lewis, David J M

N1 - 043139, Wellcome Trust, United Kingdom

PY - 2006/4

Y1 - 2006/4

N2 - Oral immunization of healthy adults with 107 CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

AB - Oral immunization of healthy adults with 107 CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

U2 - 10.1128/IAI.74.4.2449-2452.2006

DO - 10.1128/IAI.74.4.2449-2452.2006

M3 - Article

C2 - 16552077

SN - 1098-5522

VL - 74

SP - 2449

EP - 2452

JO - Infection and immunity

JF - Infection and immunity

IS - 4

ER -

Cosgrove CA, Castello-Branco LRR, Hussell T, Sexton A, Giemza R, Phillips R et al. Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine. Infection and immunity. 2006 Apr;74(4):2449-2452. doi: 10.1128/IAI.74.4.2449-2452.2006