Brain hemispheric structural efficiency and interconnectivity rightward asymmetry in human and nonhuman primates

Yasser Iturria-Medina, Alejandro Pérez Fernández, David M. Morris, Erick J. Canales-Rodríguez, Hamied A. Haroon, Lorna García Pentón, Mark Augath, Lídice Galán García, Nikos Logothetis, Geoffrey J M Parker, Lester Melie-García

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Evidence for interregional structural asymmetries has been previously reported for brain anatomic regions supporting welldescribed functional lateralization. Here, we aimed to investigate whether the two brain hemispheres demonstrate dissimilar general structural attributes implying different principles on information flow management. Common left hemisphere/right hemisphere structural network properties are estimated and compared for right-handed healthy human subjects and a nonhuman primate, by means of 3 different diffusion-weighted magnetic resonance imaging fiber tractography algorithms and a graph theory framework. In both the human and the nonhuman primate, the data support the conclusion that, in terms of the graph framework, the right hemisphere is significantly more efficient and interconnected than the left hemisphere, whereas the left hemisphere presents more central or indispensable regions for the whole-brain structural network than the right hemisphere. From our point of view, in terms of functional principles, this pattern could be related with the fact that the left hemisphere has a leading role for highly demanding specific process, such as language and motor actions, which may require dedicated specialized networks, whereas the right hemisphere has a leading role for more general process, such as integration tasks, which may require a more general level of interconnection. © The Author 2010. Published by Oxford University Press. All rights reserved.
    Original languageEnglish
    Pages (from-to)56-67
    Number of pages11
    JournalCerebral Cortex
    Volume21
    Issue number1
    DOIs
    Publication statusPublished - Jan 2011

    Keywords

    • Brain structural network
    • Diffusion-weighted mri
    • Efficiency
    • Fiber tractography
    • Hemispheric asymmetries
    • Interconnectivity

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