Brain metabolic differences between sporadic and familial Alzheimer's disease.

L Mosconi; S Sorbi; B Nacmias; Cristofaro M RT R De; M Fayyaz; E Cellini; S Bagnoli; L Bracco; Karl Herholz; [Unknown] KG; A Pupi

Brain metabolic differences between sporadic and familial Alzheimer's disease.

L Mosconi, S Sorbi, B Nacmias, Cristofaro M RT R De, M Fayyaz, E Cellini, S Bagnoli, L Bracco, Karl Herholz, [Unknown] KG, A Pupi

Research output: Contribution to journal › Article › peer-review

Abstract

Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy.This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p <0.001). Genetic factors lead to phenotypic differences in AD.PMID: 14581683 [PubMed - indexed for MEDLINE]

Original language	English
Journal	Neurology
Volume	61(8)
Publication status	Published - 2003

Cite this

@article{5151e1fa779e472faa58874db9f7a7be,

title = "Brain metabolic differences between sporadic and familial Alzheimer's disease.",

abstract = "Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy.This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p <0.001). Genetic factors lead to phenotypic differences in AD.PMID: 14581683 [PubMed - indexed for MEDLINE]",

author = "L Mosconi and S Sorbi and B Nacmias and De, {Cristofaro M RT R} and M Fayyaz and E Cellini and S Bagnoli and L Bracco and Karl Herholz and [Unknown] KG and A Pupi",

year = "2003",

language = "English",

volume = "61(8)",

journal = "Neurology",

issn = "1526-632X",

publisher = "Lippincott Williams & Wilkins",

}

TY - JOUR

T1 - Brain metabolic differences between sporadic and familial Alzheimer's disease.

AU - Mosconi, L

AU - Sorbi, S

AU - Nacmias, B

AU - De, Cristofaro M RT R

AU - Fayyaz, M

AU - Cellini, E

AU - Bagnoli, S

AU - Bracco, L

AU - Herholz, Karl

AU - KG, [Unknown]

AU - Pupi, A

PY - 2003

Y1 - 2003

N2 - Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy.This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p <0.001). Genetic factors lead to phenotypic differences in AD.PMID: 14581683 [PubMed - indexed for MEDLINE]

AB - Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy.This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p <0.001). Genetic factors lead to phenotypic differences in AD.PMID: 14581683 [PubMed - indexed for MEDLINE]

M3 - Article

SN - 1526-632X

VL - 61(8)

JO - Neurology

JF - Neurology

ER -

Brain metabolic differences between sporadic and familial Alzheimer's disease.

Abstract

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