TY - JOUR
T1 - Branch-Selective Alkene Hydroarylation by Cooperative Destabilization
T2 - Iridium-Catalyzed ortho-Alkylation of Acetanilides
AU - Crisenza, Giacomo
AU - Sokolova, Olga O.
AU - Bower, John F.
PY - 2015/10/22
Y1 - 2015/10/22
N2 - An iridium(I) catalyst system, modified with the wide-bite-angle and electron-deficient bisphosphine dFppb (1,4-bis(di(pentafluorophenyl)phosphino)butane) promotes highly branch-selective hydroarylation reactions between diverse acetanilides and aryl- or alkyl-substituted alkenes. This provides direct and ortho-selective access to synthetically challenging anilines, and addresses long-standing issues associated with related Friedel–Crafts alkylations.
AB - An iridium(I) catalyst system, modified with the wide-bite-angle and electron-deficient bisphosphine dFppb (1,4-bis(di(pentafluorophenyl)phosphino)butane) promotes highly branch-selective hydroarylation reactions between diverse acetanilides and aryl- or alkyl-substituted alkenes. This provides direct and ortho-selective access to synthetically challenging anilines, and addresses long-standing issues associated with related Friedel–Crafts alkylations.
UR - http://dx.doi.org/10.1002/anie.201506581
U2 - 10.1002/anie.201506581
DO - 10.1002/anie.201506581
M3 - Article
SN - 1433-7851
VL - 54
SP - 14866
EP - 14870
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
IS - 49
ER -