BRCA carriers, prophylactic salpingo-oophorectomy and menopause: Clinical management considerations and recommendations

Amy Finch, Gareth Evans, Steven A. Narod

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Women who inherit a mutation in either the BRCA1 or BRCA2 gene have greatly elevated lifetime risks of ovarian cancer, fallopian tube cancer and breast cancer. Preventive surgical removal of the ovaries and fallopian tubes (salpingo-oophorectomy) is recommended to these women, often prior to natural menopause, to prevent cancer. The ensuing hormone deprivation may impact on health and quality of life. Most of these women experience menopausal symptoms shortly after surgery; however, there may also be longer term consequences that are less well understood. In this review, we highlight recent studies that examine the implications of salpingo-oophorectomy on health and quality of life in BRCA-positive women and we discuss the care of women following prophylactic surgery. © 2012 Future Medicine Ltd.
    Original languageEnglish
    Pages (from-to)543-555
    Number of pages12
    JournalWomen's Health
    Volume8
    Issue number5
    DOIs
    Publication statusPublished - Sept 2012

    Keywords

    • BRCA1
    • BRCA2
    • prophylactic salpingo-oophorectomy
    • surgical menopause

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