Abstract
Scald injury (30% surface scald) in the rat caused rapid (1-3 h) and transient decreases in oxygen consumption (V̇O2 20%), colonic temperature (1.1° C), and brown adipose tissue (BAT) thermogenic activity (22%). Three days after injury, V̇O2 was slightly increased in injured rats, and sympathetically mediated heat production (assessed from the inhibitory effect of a β-adrenergic antagonist on V̇O2) was significantly greater than that for controls. At this time, BAT activity (in vitro mitochondrial GDP binding) was 35% higher in injured than control rats. Food intake was inhibited for only 24 h in injured animals, but weight gain was suppressed for at least 3 days. The data indicate that sympathetic modification of BAT thermogenesis may contribute to the changes in metabolic rate and body weight gain after scald injury in the rat.
| Original language | English |
|---|---|
| Pages (from-to) | 33-36 |
| Number of pages | 3 |
| Journal | Circulatory Shock |
| Volume | 33 |
| Issue number | 1 |
| Publication status | Published - 1991 |
Keywords
- brown adipose tissue
- colonic temperature
- scald
- thermogenic activity
- V̇O2