Bullous Pemphigoid Associated with Multiple System Atrophy: Case Series

Andrew Snedden, Jennifer Sharif, Christopher Kobylecki, John Newsham

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Bullous pemphigoid (BP) is an autoimmune blistering dermatosis associated with a number of neurological conditions, including idiopathic Parkinson's disease (IPD). Only 1 case of BP in a patient with multiple system atrophy (MSA) has been reported.

Cases: We report 3 cases of men with probable MSA who developed bullous pemphigoid at a latency of 4-6 years from MSA symptom onset.

Conclusions: Skin α-synuclein deposition in neurodegenerative conditions such as IPD and MSA may be a potential substrate for the exposure of BP-related antigens. Alternatively, central neurodegeneration may expose antigens as a substrate for cross-reactivity and BP pathogenesis. Our report suggests an association between BP and MSA, in addition to the previously documented association with IPD.

Keywords: bullous pemphigoid; multiple system atrophy; skin; α‐synuclein.
Original languageEnglish
Pages (from-to)445-448
JournalMovement Disorders Clinical Practice
Volume8
Issue number3
Early online date25 Feb 2021
DOIs
Publication statusPublished - Apr 2021

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