Butyrolactone signalling circuits for synthetic biology

Marc Biarnes Carrera, Rainer Breitling, Eriko Takano

    Research output: Contribution to journalArticlepeer-review


    Signalling circuits based on quorum sensing mechanisms have been popular tools for synthetic biology. Recent advances in our understanding of the analogous systems regulating antibiotics production in soil bacteria suggest that these might provide useful complementary tools to increase the complexity of possible circuit designs. Here we discuss the diversity of these natural circuits, which use γ-butyrolactones (GBLs) as their main inter-cellular signal, highlighting the range of new building blocks they could provide, as well as a number of exciting recent applications of GBL-based circuits in heterologous systems. We conclude by presenting examples of the novel circuit complexity that could become accessible through the use of GBL-based designs.
    Original languageEnglish
    JournalCurrent Opinion in Chemical Biology
    Publication statusPublished - 8 Jul 2015


    Dive into the research topics of 'Butyrolactone signalling circuits for synthetic biology'. Together they form a unique fingerprint.

    Cite this