Butyrolactone signalling circuits for synthetic biology

Marc Biarnes Carrera; Rainer Breitling; Eriko Takano

doi:10.1016/j.cbpa.2015.06.024

Butyrolactone signalling circuits for synthetic biology

Marc Biarnes Carrera, Rainer Breitling, Eriko Takano

Research output: Contribution to journal › Article › peer-review

Abstract

Signalling circuits based on quorum sensing mechanisms have been popular tools for synthetic biology. Recent advances in our understanding of the analogous systems regulating antibiotics production in soil bacteria suggest that these might provide useful complementary tools to increase the complexity of possible circuit designs. Here we discuss the diversity of these natural circuits, which use γ-butyrolactones (GBLs) as their main inter-cellular signal, highlighting the range of new building blocks they could provide, as well as a number of exciting recent applications of GBL-based circuits in heterologous systems. We conclude by presenting examples of the novel circuit complexity that could become accessible through the use of GBL-based designs.

Original language	English
Journal	Current Opinion in Chemical Biology
Volume	28
DOIs	https://doi.org/10.1016/j.cbpa.2015.06.024
Publication status	Published - 8 Jul 2015

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10.1016/j.cbpa.2015.06.024

Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals
Scrutton, N. (PI), Azapagic, A. (CoI), Balmer, A. (CoI), Barran, P. (CoI), Breitling, R. (CoI), Delneri, D. (CoI), Dixon, N. (CoI), Faulon, J.-L. (CoI), Flitsch, S. (CoI), Goble, C. (CoI), Goodacre, R. (CoI), Hay, S. (CoI), Kell, D. (CoI), Leys, D. (CoI), Lloyd, J. (CoI), Lockyer, N. (CoI), Martin, P. (CoI), Micklefield, J. (CoI), Munro, A. (CoI), Pedrosa Mendes, P. (CoI), Randles, S. (CoI), Salehi Yazdi, F. (CoI), Shapira, P. (CoI), Takano, E. (CoI), Turner, N. (CoI) & Winterburn, J. (CoI)
14/11/14 → 13/05/20
Project: Research

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@article{e4198347d05d472db20e8414b56d9139,

title = "Butyrolactone signalling circuits for synthetic biology",

abstract = "Signalling circuits based on quorum sensing mechanisms have been popular tools for synthetic biology. Recent advances in our understanding of the analogous systems regulating antibiotics production in soil bacteria suggest that these might provide useful complementary tools to increase the complexity of possible circuit designs. Here we discuss the diversity of these natural circuits, which use γ-butyrolactones (GBLs) as their main inter-cellular signal, highlighting the range of new building blocks they could provide, as well as a number of exciting recent applications of GBL-based circuits in heterologous systems. We conclude by presenting examples of the novel circuit complexity that could become accessible through the use of GBL-based designs.",

author = "{Biarnes Carrera}, Marc and Rainer Breitling and Eriko Takano",

note = "We would like to acknowledge the BBSRC, EPSRC funded Manchester Synthetic Biology Research Centre, SYNBIOCHEM (BB/M017702/1).",

year = "2015",

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doi = "10.1016/j.cbpa.2015.06.024",

language = "English",

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journal = "Current Opinion in Chemical Biology",

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T1 - Butyrolactone signalling circuits for synthetic biology

AU - Biarnes Carrera, Marc

AU - Breitling, Rainer

AU - Takano, Eriko

N1 - We would like to acknowledge the BBSRC, EPSRC funded Manchester Synthetic Biology Research Centre, SYNBIOCHEM (BB/M017702/1).

PY - 2015/7/8

Y1 - 2015/7/8

N2 - Signalling circuits based on quorum sensing mechanisms have been popular tools for synthetic biology. Recent advances in our understanding of the analogous systems regulating antibiotics production in soil bacteria suggest that these might provide useful complementary tools to increase the complexity of possible circuit designs. Here we discuss the diversity of these natural circuits, which use γ-butyrolactones (GBLs) as their main inter-cellular signal, highlighting the range of new building blocks they could provide, as well as a number of exciting recent applications of GBL-based circuits in heterologous systems. We conclude by presenting examples of the novel circuit complexity that could become accessible through the use of GBL-based designs.

AB - Signalling circuits based on quorum sensing mechanisms have been popular tools for synthetic biology. Recent advances in our understanding of the analogous systems regulating antibiotics production in soil bacteria suggest that these might provide useful complementary tools to increase the complexity of possible circuit designs. Here we discuss the diversity of these natural circuits, which use γ-butyrolactones (GBLs) as their main inter-cellular signal, highlighting the range of new building blocks they could provide, as well as a number of exciting recent applications of GBL-based circuits in heterologous systems. We conclude by presenting examples of the novel circuit complexity that could become accessible through the use of GBL-based designs.

U2 - 10.1016/j.cbpa.2015.06.024

DO - 10.1016/j.cbpa.2015.06.024

M3 - Article

C2 - 26164547

SN - 1879-0402

VL - 28

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

ER -

Butyrolactone signalling circuits for synthetic biology

Abstract

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Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals

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