C-Myb function in the vessel wall

Kelly A. Farrell, Sarah B. Withers, Cathy M. Holt

    Research output: Contribution to journalArticlepeer-review


    C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of C-Myb in vascular injury has been investigated previously both in vitro and in vivo, where knock-down of C-Myb is known to lead to a reduction in proliferation and an increase in apoptosis of vascular smooth muscle cells (VSMCs). Reduction of C-Myb activity has also been shown to decrease neointimal formation in vivo, by reducing VSMC proliferation. In contrast, over-expression of C-Myb in vivo leads to increased survival rates in certain cell types. This review will look mainly at studies investigating C-Myb function in the vasculature, and evidence of signalling interactions which may be considered with regard to C-Myb as a possible target in the treatment of vasculoproliferative diseases.
    Original languageEnglish
    Pages (from-to)968-977
    Number of pages9
    JournalFrontiers in Bioscience - Elite
    Issue number3
    Publication statusPublished - 6 Jan 2011


    • Angioplasty
    • Antisense
    • Apoptosis
    • Atherosclerosis
    • C-Myb
    • Knock-down
    • Myb Engrailed
    • Neointima
    • Proliferation
    • Review
    • Smooth muscle


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