TY - JOUR
T1 - C reactive protein and chronic obstructive pulmonary disease: A Mendelian randomisation approach
AU - Vestbo, Jorgen
AU - Dahl, Morten
AU - Vestbo, Jørgen
AU - Zacho, Jeppe
AU - Lange, Peter
AU - Tybjærg-Hansen, Anne
AU - Nordestgaard, Børge G.
PY - 2011/3
Y1 - 2011/3
N2 - Background: It is unclear whether elevated plasma C reactive protein (CRP) is causally related to chronic obstructive pulmonary disease (COPD). The authors tested the hypothesis that genetically elevated plasma CRP causes COPD using a Mendelian randomisation design. Methods: The authors measured high-sensitivity CRP in plasma, genotyped for four single nucleotide polymorphisms in the CRP gene, and screened for spirometry-defined COPD and hospitalisation due to COPD in 7974 individuals from the Copenhagen City Heart Study and in 32 652 individuals from the Copenhagen General Population Study. Results: Elevated plasma CRP >3 mg/l compared with
AB - Background: It is unclear whether elevated plasma C reactive protein (CRP) is causally related to chronic obstructive pulmonary disease (COPD). The authors tested the hypothesis that genetically elevated plasma CRP causes COPD using a Mendelian randomisation design. Methods: The authors measured high-sensitivity CRP in plasma, genotyped for four single nucleotide polymorphisms in the CRP gene, and screened for spirometry-defined COPD and hospitalisation due to COPD in 7974 individuals from the Copenhagen City Heart Study and in 32 652 individuals from the Copenhagen General Population Study. Results: Elevated plasma CRP >3 mg/l compared with
U2 - 10.1136/thx.2009.131193
DO - 10.1136/thx.2009.131193
M3 - Article
C2 - 21059738
SN - 0040-6376
VL - 66
SP - 197
EP - 204
JO - Thorax
JF - Thorax
IS - 3
ER -