C-reactive Protein as a Predictor of Prognosis in COPD.

M Dahl, J Vestbo, P Lange, SE Bojesen, A Tybjaerg-Hansen, BG. Nordestgaard

    Research output: Contribution to journalArticlepeer-review


    RATIONALE: Patients with COPD have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP). OBJECTIVE: To determine whether increased serum CRP in individuals with airway obstruction predict future hospitalization and death from COPD. METHODS: We performed a cohort study with a median of 8-years follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study. MEASUREMENTS AND MAIN RESULTS: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died from COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP >3mg/L vs. 3mg/L vs.
    Original languageEnglish
    Journal American Journal of Respiratory and Critical Care Medicine
    Publication statusPublished - 1 Feb 2006


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