C-reactive protein predicts hematoma growth in intracerebral hemorrhage

Mario Di Napoli, Adrian R. Parry-Jones, Craig J. Smith, Stephen J. Hopkins, Mark Slevin, Luca Masotti, Veronica Campi, Puneetpal Singh, Francesca Papa, Aurel Popa-Wagner, Valerica Tudorica, Daniel Agustin Godoy

    Research output: Contribution to journalArticlepeer-review


    Background and Purpose-Early hematoma growth (EHG) occurs in about one third of patients with spontaneous intracerebral hemorrhage. The main aim of this study was to investigate the potential of plasma C-reactive protein (CRP) for predicting EHG after acute spontaneous intracerebral hemorrhage. Methods-Plasma CRP was measured within 6 hours of onset (median, 120 minutes) in 399 patients with primary or vitamin K antagonist-associated spontaneous intracerebral hemorrhage and without recent infection. Computed tomography brain scans were performed at baseline and repeated within 24 hours (median, 22 hours). The primary outcome was EHG, defined as absolute growth >12.5 cm3 or relative growth >33%. Secondary outcomes included early neurological worsening (ENW) using the Glasgow Coma Scale and 30-day mortality. Multivariable regression analyses were used to evaluate associations of CRP concentration and outcomes. Kaplan-Meier analysis was used for survival. Results-EHG occurred in 25.8%, ENW in 19.3%, and mortality was 31.8% at 30 days. Thirty-day mortality was significantly higher in patients with ENW (hazard ratio, 3.21; 95% confidence interval, 2.00-5.17; P10 mg/L independently predicted EHG (odds ratio, 4.71; 95% confidence interval, 2.75-8.06; P10 mg/L is independently predictive of EHG and ENW, both of which are associated with increased mortality. Inflammation may be important in contributing to EHG and warrants further investigation. © 2013 American Heart Association, Inc.
    Original languageEnglish
    Pages (from-to)59-65
    Number of pages6
    Issue number1
    Publication statusPublished - Jan 2014


    • C-reactive protein
    • Cerebral hemorrhage
    • Inflammation
    • Prognosis


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