C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham offspring study

Martin Rutter; Martin K. Rutter; James B. Meigs; Lisa M. Sullivan; Ralph B. D'Agostino; Peter W F Wilson

doi:10.1161/01.CIR.0000136581.59584.0E

C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham offspring study

Martin Rutter, Martin K. Rutter, James B. Meigs, Lisa M. Sullivan, Ralph B. D'Agostino, Peter W F Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Background - Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. Methods and Results - We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. MetS (≥3 of 5 traits) was present in 24% of subjects; mean age-adjusted CRP levels for those with 0, 1, 2, 3, 4, or 5 MetS traits were 2.2, 3.5, 4.2, 6.0, or 6.6 mg/L, respectively (P trend

Original language	English
Pages (from-to)	380-385
Number of pages	5
Journal	Circulation
Volume	110
Issue number	4
DOIs	https://doi.org/10.1161/01.CIR.0000136581.59584.0E
Publication status	Published - 27 Jul 2004

Keywords

C-reactive protein
Cardiovascular diseases
Insulin
Prognosis
Risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/01.CIR.0000136581.59584.0E

Cite this

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title = "C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham offspring study",

abstract = "Background - Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. Methods and Results - We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. MetS (≥3 of 5 traits) was present in 24% of subjects; mean age-adjusted CRP levels for those with 0, 1, 2, 3, 4, or 5 MetS traits were 2.2, 3.5, 4.2, 6.0, or 6.6 mg/L, respectively (P trend",

keywords = "C-reactive protein, Cardiovascular diseases, Insulin, Prognosis, Risk factors",

author = "Martin Rutter and Rutter, {Martin K.} and Meigs, {James B.} and Sullivan, {Lisa M.} and D'Agostino, {Ralph B.} and Wilson, {Peter W F}",

note = "N01-HC-25195, NHLBI NIH HHS, United StatesR01-HL-073272-01, NHLBI NIH HHS, United States",

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T1 - C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham offspring study

AU - Rutter, Martin

AU - Rutter, Martin K.

AU - Meigs, James B.

AU - Sullivan, Lisa M.

AU - D'Agostino, Ralph B.

AU - Wilson, Peter W F

N1 - N01-HC-25195, NHLBI NIH HHS, United StatesR01-HL-073272-01, NHLBI NIH HHS, United States

PY - 2004/7/27

Y1 - 2004/7/27

N2 - Background - Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. Methods and Results - We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. MetS (≥3 of 5 traits) was present in 24% of subjects; mean age-adjusted CRP levels for those with 0, 1, 2, 3, 4, or 5 MetS traits were 2.2, 3.5, 4.2, 6.0, or 6.6 mg/L, respectively (P trend

AB - Background - Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. Methods and Results - We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. MetS (≥3 of 5 traits) was present in 24% of subjects; mean age-adjusted CRP levels for those with 0, 1, 2, 3, 4, or 5 MetS traits were 2.2, 3.5, 4.2, 6.0, or 6.6 mg/L, respectively (P trend

KW - C-reactive protein

KW - Cardiovascular diseases

KW - Insulin

KW - Prognosis

KW - Risk factors

U2 - 10.1161/01.CIR.0000136581.59584.0E

DO - 10.1161/01.CIR.0000136581.59584.0E

M3 - Article

C2 - 15262834

SN - 0009-7322

VL - 110

SP - 380

EP - 385

JO - Circulation

JF - Circulation

IS - 4

ER -

C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham offspring study

Abstract

Keywords

UN SDGs

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