Ca 2+ regulation and gene expression in normal brain aging

Emil C. Toescu; Alexei Verkhratsky; Philip W. Landfield

doi:10.1016/j.tins.2004.07.010

Ca 2+ regulation and gene expression in normal brain aging

Emil C. Toescu
, Alexei Verkhratsky
, Philip W. Landfield

Research output: Contribution to journal › Article › peer-review

Abstract

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca 2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca 2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

Original language	English
Pages (from-to)	614-620
Number of pages	6
Journal	Trends in neurosciences
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/j.tins.2004.07.010
Publication status	Published - Oct 2004

Access to Document

10.1016/j.tins.2004.07.010

Cite this

@article{239113bf74424e138024b5af7349593c,

title = "Ca 2+ regulation and gene expression in normal brain aging",

abstract = "Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca 2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca 2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.",

author = "Toescu, \{Emil C.\} and Alexei Verkhratsky and Landfield, \{Philip W.\}",

year = "2004",

month = oct,

doi = "10.1016/j.tins.2004.07.010",

language = "English",

volume = "27",

pages = "614--620",

journal = "Trends in neurosciences",

issn = "0166-2236",

publisher = "Elsevier BV",

number = "10",

}

TY - JOUR

T1 - Ca 2+ regulation and gene expression in normal brain aging

AU - Toescu, Emil C.

AU - Verkhratsky, Alexei

AU - Landfield, Philip W.

PY - 2004/10

Y1 - 2004/10

N2 - Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca 2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca 2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

AB - Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca 2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca 2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

U2 - 10.1016/j.tins.2004.07.010

DO - 10.1016/j.tins.2004.07.010

M3 - Article

SN - 0166-2236

VL - 27

SP - 614

EP - 620

JO - Trends in neurosciences

JF - Trends in neurosciences

IS - 10

ER -

Ca 2+ regulation and gene expression in normal brain aging

Abstract

Access to Document

Fingerprint

Cite this