Ca2+ channels and epilepsy

Owen T. Jones

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The epilepsies encompass diverse seizure disorders afflicting as many as 50 million people worldwide. Many forms of epilepsy are intractable to current therapies and there is a pressing need to develop agents and strategies to not only suppress seizures, but also cure epilepsy. Recent insights from molecular genetics and pharmacology now point to an important role for voltage-dependent calcium channels in epilepsy. In this article, I first provide an introduction to the classification of the epilepsies and an overview of neuronal Ca2+ channels. Next, I attempt to review the evidence for a role of Ca2+ channels in epilepsy and the insights gained from genetics and pharmacology. Lastly, I describe new avenues for how such information might be exploited in the development of therapeutic reagents. © 2002 Elsevier Science B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)211-225
    Number of pages14
    JournalEuropean journal of pharmacology
    Volume447
    Issue number2-3
    DOIs
    Publication statusPublished - 5 Jul 2002

    Keywords

    • Molecular genetics
    • Pharmacology
    • Voltage-dependent calcium channel

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