Ca2+ currents in cardiac myocytes: Old story, new insights

Fabien Brette, Jérôme Leroy, Jean Yves Le Guennec, Laurent Sallé

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Calcium is a ubiquitous second messenger which plays key roles in numerous physiological functions. In cardiac myocytes, Ca2+ crosses the plasma membrane via specialized voltage-gated Ca2+ channels which have two main functions: (i) carrying depolarizing current by allowing positively charged Ca2+ ions to move into the cell; (ii) triggering Ca2+ release from the sarcoplasmic reticulum. Recently, it has been suggested than Ca2+ channels also participate in excitation-transcription coupling. The purpose of this review is to discuss the physiological roles of Ca 2+ currents in cardiac myocytes. Next, we describe local regulation of Ca2+ channels by cyclic nucleotides. We also provide an overview of recent studies investigating the structure-function relationship of Ca 2+ channels in cardiac myocytes using heterologous system expression and transgenic mice, with descriptions of the recently discovered Ca 2+ channels α1D and α1E. We finally discuss the potential involvement of Ca2+ currents in cardiac pathologies, such as diseases with autoimmune components, and cardiac remodeling. © 2005 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)1-82
    Number of pages81
    JournalProgress in biophysics and molecular biology
    Volume91
    Issue number1-2
    DOIs
    Publication statusPublished - May 2006

    Keywords

    • Auto immune
    • Calcium current
    • Cardiac
    • L-type calcium channel
    • Modulation
    • Myocytes
    • Remodeling
    • T-type calcium channel

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