Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin e

Daopeng Yuan; Anthony H. Keeble; Richard G. Hibbert; Stella Fabiane; Hannah J. Gould; James M. McDonnell; Andrew J. Beavil; Brian J. Sutton; Balvinder Dhaliwal

doi:10.1074/jbc.M113.480657

Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin e

Daopeng Yuan, Anthony H. Keeble, Richard G. Hibbert, Stella Fabiane, Hannah J. Gould, James M. McDonnell, Andrew J. Beavil, Brian J. Sutton, Balvinder Dhaliwal

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Immunoglobulin E (IgE) plays a central role in allergic disease. The B-cell receptor CD23 is pivotal in regulating IgE synthesis. Results: Ca2+-dependent structural changes in CD23 enable additional interactions with IgE. Conclusion: Mechanism for Ca2+-induced increase in affinity is revealed. Significance: Ca2+ binding brings an extra degree of modulation to CD23 function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Original language	English
Pages (from-to)	21667-21677
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.480657
Publication status	Published - 26 Jul 2013

Keywords

Allergy
CD23
Calcium
FC Receptors
Immunoglobulin E
Immunology
X-ray Crystallography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1074/jbc.M113.480657

http://www.jbc.org/content/288/30/21667.full.pdf+html

Cite this

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title = "Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin e",

abstract = "Background: Immunoglobulin E (IgE) plays a central role in allergic disease. The B-cell receptor CD23 is pivotal in regulating IgE synthesis. Results: Ca2+-dependent structural changes in CD23 enable additional interactions with IgE. Conclusion: Mechanism for Ca2+-induced increase in affinity is revealed. Significance: Ca2+ binding brings an extra degree of modulation to CD23 function. {\textcopyright} 2013 by The American Society for Biochemistry and Molecular Biology, Inc.",

keywords = "Allergy, CD23, Calcium, FC Receptors, Immunoglobulin E, Immunology, X-ray Crystallography",

author = "Daopeng Yuan and Keeble, {Anthony H.} and Hibbert, {Richard G.} and Stella Fabiane and Gould, {Hannah J.} and McDonnell, {James M.} and Beavil, {Andrew J.} and Sutton, {Brian J.} and Balvinder Dhaliwal",

note = "G0501494, Medical Research Council, United KingdomG1100090, Medical Research Council, United KingdomMR/J006742/1, Medical Research Council, United Kingdom, Medical Research Council, United Kingdom, Wellcome Trust, United Kingdom",

year = "2013",

month = jul,

day = "26",

doi = "10.1074/jbc.M113.480657",

language = "English",

volume = "288",

pages = "21667--21677",

journal = "Journal of Biological Chemistry",

issn = "1083-351X",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "30",

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TY - JOUR

T1 - Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin e

AU - Yuan, Daopeng

AU - Keeble, Anthony H.

AU - Hibbert, Richard G.

AU - Fabiane, Stella

AU - Gould, Hannah J.

AU - McDonnell, James M.

AU - Beavil, Andrew J.

AU - Sutton, Brian J.

AU - Dhaliwal, Balvinder

N1 - G0501494, Medical Research Council, United KingdomG1100090, Medical Research Council, United KingdomMR/J006742/1, Medical Research Council, United Kingdom, Medical Research Council, United Kingdom, Wellcome Trust, United Kingdom

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: Immunoglobulin E (IgE) plays a central role in allergic disease. The B-cell receptor CD23 is pivotal in regulating IgE synthesis. Results: Ca2+-dependent structural changes in CD23 enable additional interactions with IgE. Conclusion: Mechanism for Ca2+-induced increase in affinity is revealed. Significance: Ca2+ binding brings an extra degree of modulation to CD23 function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

AB - Background: Immunoglobulin E (IgE) plays a central role in allergic disease. The B-cell receptor CD23 is pivotal in regulating IgE synthesis. Results: Ca2+-dependent structural changes in CD23 enable additional interactions with IgE. Conclusion: Mechanism for Ca2+-induced increase in affinity is revealed. Significance: Ca2+ binding brings an extra degree of modulation to CD23 function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

KW - Allergy

KW - CD23

KW - Calcium

KW - FC Receptors

KW - Immunoglobulin E

KW - Immunology

KW - X-ray Crystallography

U2 - 10.1074/jbc.M113.480657

DO - 10.1074/jbc.M113.480657

M3 - Article

C2 - 23775083

SN - 1083-351X

VL - 288

SP - 21667

EP - 21677

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 30

ER -

Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin e

Abstract

Keywords

UN SDGs

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