Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle.

T Heppner; G Herrera; A Bonev; D Hill-Eubanks; MT. Nelson

Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle.

T Heppner, G Herrera, A Bonev, D Hill-Eubanks, MT. Nelson

Research output: Contribution to journal › Article › peer-review

Abstract

Negative feedback pathways that relax and stabilize UBSM are critical to the proper functioning of the urinary bladder. The complex interactions between K(Ca) channels and RyRs are just beginning to be unraveled. The consequences of SK, BK, and RyR dysfunction would increase cell excitability and lead to urinary bladder instability. Although each of these channels is a potential target for the development of therapeutics to treat urinary incontinence, SK is of special interest, since this SK isoform does not appear to be present in vascular smooth muscle.

Original language	English
Journal	Advances in Experimental Medicine and Biology
Volume	539( Pt A)
Publication status	Published - 2003

Keywords

Animals
physiology: Calcium Channels
physiology: Calcium Signaling
Humans
physiology: Muscle Relaxation
physiology: Muscle, Smooth
physiology: Potassium Channels
physiology: Urinary Bladder

Cite this

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title = "Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle.",

abstract = "Negative feedback pathways that relax and stabilize UBSM are critical to the proper functioning of the urinary bladder. The complex interactions between K(Ca) channels and RyRs are just beginning to be unraveled. The consequences of SK, BK, and RyR dysfunction would increase cell excitability and lead to urinary bladder instability. Although each of these channels is a potential target for the development of therapeutics to treat urinary incontinence, SK is of special interest, since this SK isoform does not appear to be present in vascular smooth muscle.",

keywords = "Animals, physiology: Calcium Channels, physiology: Calcium Signaling, Humans, physiology: Muscle Relaxation, physiology: Muscle, Smooth, physiology: Potassium Channels, physiology: Urinary Bladder",

author = "T Heppner and G Herrera and A Bonev and D Hill-Eubanks and MT. Nelson",

year = "2003",

language = "English",

volume = "539( Pt A)",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

publisher = "Springer Nature",

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TY - JOUR

T1 - Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle.

AU - Heppner, T

AU - Herrera, G

AU - Bonev, A

AU - Hill-Eubanks, D

AU - Nelson, MT.

PY - 2003

Y1 - 2003

N2 - Negative feedback pathways that relax and stabilize UBSM are critical to the proper functioning of the urinary bladder. The complex interactions between K(Ca) channels and RyRs are just beginning to be unraveled. The consequences of SK, BK, and RyR dysfunction would increase cell excitability and lead to urinary bladder instability. Although each of these channels is a potential target for the development of therapeutics to treat urinary incontinence, SK is of special interest, since this SK isoform does not appear to be present in vascular smooth muscle.

AB - Negative feedback pathways that relax and stabilize UBSM are critical to the proper functioning of the urinary bladder. The complex interactions between K(Ca) channels and RyRs are just beginning to be unraveled. The consequences of SK, BK, and RyR dysfunction would increase cell excitability and lead to urinary bladder instability. Although each of these channels is a potential target for the development of therapeutics to treat urinary incontinence, SK is of special interest, since this SK isoform does not appear to be present in vascular smooth muscle.

KW - Animals

KW - physiology: Calcium Channels

KW - physiology: Calcium Signaling

KW - Humans

KW - physiology: Muscle Relaxation

KW - physiology: Muscle, Smooth

KW - physiology: Potassium Channels

KW - physiology: Urinary Bladder

M3 - Article

SN - 0065-2598

VL - 539( Pt A)

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle.

Abstract

Keywords

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