Calcitonin gene-related peptide-1 (CGRP-1) is a potent regulator of glycogen metabolism in rat skeletal muscle

Brendan Leighton, Elizabeth A. Foot, Garth Cooper, Jayne M. King

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effects of CGRP on glucose metabolism in intact rat skeletal muscle preparations that are largely composed of either type I (soleus) or II fibres (e.g. extensor digitorum longus (EDL) or epitrochlearis muscles). CGRP-1 inhibited insulin-stimulated glycogen synthesis in both soleus and EDL muscle preparations. Rat CGRP-1 was a potent stimulator of glycogenolysis only in muscles composed of type II fibres, which depend on high rates of glycogenolysis to produce high power outputs. These results may provide the basis for understanding how CGRP regulate glycogenolysis in type II fibres in vivo. © 1989.
Original languageEnglish
Pages (from-to)357-361
Number of pages4
JournalFEBS Letters
Volume249
Issue number2
DOIs
Publication statusPublished - 5 Jun 1989

Keywords

  • Amylin
  • Diabetes mellitus
  • Insulin resistance

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