Calcium-induced calcium release activates contraction in intact cardiac cells

M. Valdeolmillos, S. C. O'Neill, G. L. Smith, D. A. Eisner

    Research output: Contribution to journalArticlepeer-review


    The "caged" calcium chelator Nitr-5 was Incorporated into isolated rat ventricular myocytes. Brief illumination with ultra-violet light made the cell twitch. The light-induced twitch was inhibited by ryanodine (1-10 μM) suggesting that it resulted from calcium-induced release of calcium from the sarcoplasmic reticulum. Inhibition of the Ca current (Ni, 10 mM) abolished the electrically stimulated twitch but did not inhibit the light-induced twitch. These results provide direct evidence for the importance of Ca-induced Ca release in excitation-contraction coupling in the heart. © 1989 Springer-Verlag.
    Original languageEnglish
    Pages (from-to)676-678
    Number of pages2
    JournalPflügers Archiv European Journal of Physiology
    Issue number6
    Publication statusPublished - Apr 1989


    • caged Ca
    • Cardiac myocyte
    • contraction
    • sarcoplasmic reticulum


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