cAMP signaling in Dictyostelium: Complexity of cAMP synthesis, degradation and detection

Shweta Saran; Marcel E. Meima; Elisa Alvarez-Curto; Karin E. Weening; Daniel E. Rozen; Pauline Schaap

doi:10.1023/A:1024483829878

cAMP signaling in Dictyostelium: Complexity of cAMP synthesis, degradation and detection

Shweta Saran, Marcel E. Meima, Elisa Alvarez-Curto, Karin E. Weening, Daniel E. Rozen, Pauline Schaap

Research output: Contribution to journal › Article › peer-review

Abstract

cAMP plays a pivotal role in control of cell movement, differentiation and response to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP require precise spatial and temporal control of its production, degradation and detection. Many novel proteins have recently been identified that critically modulate the cAMP signal. We focus in this review on the properties and functions of the three adenylyl cyclases and the three cAMP-phosphodiesterases that are present in Dictyostelium, and the network of proteins that regulate the activity of these enzymes. We also briefly discuss the two modes of detection of cAMP.

Original language	English
Pages (from-to)	793-802
Number of pages	9
Journal	Journal of Muscle Research and Cell Motility
Volume	23
Issue number	7-8
DOIs	https://doi.org/10.1023/A:1024483829878
Publication status	Published - 2002

Access to Document

10.1023/A:1024483829878

Cite this

@article{a1f235e882b34ff08af19ea867645fa2,

title = "cAMP signaling in Dictyostelium: Complexity of cAMP synthesis, degradation and detection",

abstract = "cAMP plays a pivotal role in control of cell movement, differentiation and response to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP require precise spatial and temporal control of its production, degradation and detection. Many novel proteins have recently been identified that critically modulate the cAMP signal. We focus in this review on the properties and functions of the three adenylyl cyclases and the three cAMP-phosphodiesterases that are present in Dictyostelium, and the network of proteins that regulate the activity of these enzymes. We also briefly discuss the two modes of detection of cAMP.",

author = "Shweta Saran and Meima, {Marcel E.} and Elisa Alvarez-Curto and Weening, {Karin E.} and Rozen, {Daniel E.} and Pauline Schaap",

year = "2002",

doi = "10.1023/A:1024483829878",

language = "English",

volume = "23",

pages = "793--802",

journal = "Journal of Muscle Research and Cell Motility",

issn = "1573-2657",

publisher = "Springer Nature",

number = "7-8",

}

TY - JOUR

T1 - cAMP signaling in Dictyostelium: Complexity of cAMP synthesis, degradation and detection

AU - Saran, Shweta

AU - Meima, Marcel E.

AU - Alvarez-Curto, Elisa

AU - Weening, Karin E.

AU - Rozen, Daniel E.

AU - Schaap, Pauline

PY - 2002

Y1 - 2002

N2 - cAMP plays a pivotal role in control of cell movement, differentiation and response to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP require precise spatial and temporal control of its production, degradation and detection. Many novel proteins have recently been identified that critically modulate the cAMP signal. We focus in this review on the properties and functions of the three adenylyl cyclases and the three cAMP-phosphodiesterases that are present in Dictyostelium, and the network of proteins that regulate the activity of these enzymes. We also briefly discuss the two modes of detection of cAMP.

AB - cAMP plays a pivotal role in control of cell movement, differentiation and response to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP require precise spatial and temporal control of its production, degradation and detection. Many novel proteins have recently been identified that critically modulate the cAMP signal. We focus in this review on the properties and functions of the three adenylyl cyclases and the three cAMP-phosphodiesterases that are present in Dictyostelium, and the network of proteins that regulate the activity of these enzymes. We also briefly discuss the two modes of detection of cAMP.

U2 - 10.1023/A:1024483829878

DO - 10.1023/A:1024483829878

M3 - Article

C2 - 12952077

SN - 1573-2657

VL - 23

SP - 793

EP - 802

JO - Journal of Muscle Research and Cell Motility

JF - Journal of Muscle Research and Cell Motility

IS - 7-8

ER -

cAMP signaling in Dictyostelium: Complexity of cAMP synthesis, degradation and detection

Abstract

Access to Document

Fingerprint

Cite this