Can endogenous gaseous messengers control mitochondrial biogenesis in mammalian cells?

Enzo Nisoli, Emilio Clementi, Cristina Tonello, Salvador Moncada, Michele O. Carruba

    Research output: Contribution to journalArticlepeer-review


    Mitochondria have been identified as the site of oxidative energy metabolism and of numerous biosynthetic and degradative reactions, which depend on a distinctive mitochondrial structure, with different enzymes and reactions localised in discrete membranes and aqueous compartments. Synthesis and import of mitochondrial components are required for mitochondrial proliferation, but rather than producing new organelles, these processes may facilitate the growth of preexisting mitochondria. Recent evidence indicates that these events are regulated in a complex way by several agonists and environmental conditions, through activation of specific transcription factors and signaling pathways. Some of these are now being elucidated. Generation of nitric oxide (NO) appears to be a novel player in this scenario, possibly acting as a unifying molecular switch to trigger the whole process of the mitochondrial biogenesis. © 2004 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)9-27
    Number of pages18
    JournalProstaglandins and Other Lipid Mediators
    Issue number1-2
    Publication statusPublished - Jan 2004


    • BAT
    • Brown adipose tissue
    • Carbon monoxide
    • CO
    • Mitochondrial DNA
    • Mitochondrial oxidative phosphorylation
    • mtDNA
    • Nitric oxide
    • NO
    • NRF
    • Nuclear respiratory factor
    • OXPHOS
    • Peroxisome proliferator-activated receptor-γ coactivator 1α
    • PGC-1α
    • ROI


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