Cancer stem cell metabolism

Maria Peiris Pages, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Federica Sotgia, Michael Lisanti

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.

    Original languageEnglish
    Article number55
    JournalBreast Cancer Research
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - 24 May 2016

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