Candida tropicalis in human disease

Louis Yi Ann Chai, David W. Denning, Peter Warn

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Candida tropicalis is one of the more common Candida causing human disease in tropical countries; the frequency of invasive disease varies by geography causing 366% of candidaemia. C. tropicalis is taxonomically close to C. albicans and shares many pathogenic traits. C. tropicalis is particularly virulent in neutropenic hosts commonly with hematogenous seeding to peripheral organs. For candidaemia and invasive candidiasis amphotericin B or an echinocandin are recommended as first-line treatment, with extended-spectrum triazoles acceptable alternatives. Primary fluconazole resistance is uncommon but may be induced on exposure. Physicians in regions where C. tropicalis is common need to be mindful of this lesser-described pathogen. © 2010 Informa Healthcare USA, Inc.
    Original languageEnglish
    Pages (from-to)282-298
    Number of pages16
    JournalCritical Reviews in Microbiology
    Volume36
    Issue number4
    DOIs
    Publication statusPublished - Nov 2010

    Keywords

    • Candida tropicalis
    • Candidiasis
    • Candidosis

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