Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.

Edward JM Monk, Riina Rautemaa-Richardson , Timothy Felton, Alice Montalti, Matthew Parkes, Richard Templeton, Alan Ashworth, Miguel Garcia, Julian Barker, Stephanie Thomas

Research output: Contribution to journalArticlepeer-review


This single-centre retrospective study reports the dynamics of Candida bloodstream infection (CBSI) incidence in 145 patients receiving venovenous ECMO for respiratory support, between January 2014 and December 2018. Incidence rate and odds ratio (OR) of CBSI were calculated, stratified by week of ECMO exposure. Weekly incidence increased throughout the ECMO run, with a rising trend in OR (P = 0.005), and a window of continued risk after decannulation was observed. Of the 13 patients that developed CBSI, five (38%) received empirical micafungin treatment before positive culture due to clinical suspicion. Prospective studies, aiming to improve ECMO diagnostic stewardship practices and discourage antifungal prophylaxis or empiric management where unnecessary, are needed.
Original languageEnglish
JournalJournal of Hospital Infection
Publication statusAccepted/In press - 20 Sept 2021


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