Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.

Edward JM Monk; Riina Rautemaa-Richardson; Timothy Felton; Alice Montalti; Matthew Parkes; Richard Templeton; Alan Ashworth; Miguel Garcia; Julian Barker; Stephanie Thomas

Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.

Edward JM Monk, Riina Rautemaa-Richardson , Timothy Felton, Alice Montalti, Matthew Parkes, Richard Templeton, Alan Ashworth, Miguel Garcia, Julian Barker, Stephanie Thomas

Research output: Contribution to journal › Article › peer-review

Abstract

This single-centre retrospective study reports the dynamics of Candida bloodstream infection (CBSI) incidence in 145 patients receiving venovenous ECMO for respiratory support, between January 2014 and December 2018. Incidence rate and odds ratio (OR) of CBSI were calculated, stratified by week of ECMO exposure. Weekly incidence increased throughout the ECMO run, with a rising trend in OR (P = 0.005), and a window of continued risk after decannulation was observed. Of the 13 patients that developed CBSI, five (38%) received empirical micafungin treatment before positive culture due to clinical suspicion. Prospective studies, aiming to improve ECMO diagnostic stewardship practices and discourage antifungal prophylaxis or empiric management where unnecessary, are needed.

Original language	English
Journal	Journal of Hospital Infection
Publication status	Accepted/In press - 20 Sept 2021

Embargoed Document

ECMO Manuscript Final JHI Short Report Revision
Accepted author manuscript, 351 KB
Embargo ends: 1/01/31

MFIG: Manchester Fungal Infection Group (MFIG)
Bromley, M. (PI), Bertuzzi, M. (PI), Gago, S. (PI), Denning, D. (PI), Kosmidis, C. (PI), Bowyer, P. (PI), Amich Elias, J. (PI), Richardson, M. (PI), Richardson, R. (PI), Van Rhijn, N. (PI) & Bottery, M. (PI)
15/08/13 → …
Project: Research

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@article{2a0a8895635c4c2bb25d8b8324704ef1,

title = "Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.",

abstract = "This single-centre retrospective study reports the dynamics of Candida bloodstream infection (CBSI) incidence in 145 patients receiving venovenous ECMO for respiratory support, between January 2014 and December 2018. Incidence rate and odds ratio (OR) of CBSI were calculated, stratified by week of ECMO exposure. Weekly incidence increased throughout the ECMO run, with a rising trend in OR (P = 0.005), and a window of continued risk after decannulation was observed. Of the 13 patients that developed CBSI, five (38%) received empirical micafungin treatment before positive culture due to clinical suspicion. Prospective studies, aiming to improve ECMO diagnostic stewardship practices and discourage antifungal prophylaxis or empiric management where unnecessary, are needed.",

author = "Monk, {Edward JM} and Riina Rautemaa-Richardson and Timothy Felton and Alice Montalti and Matthew Parkes and Richard Templeton and Alan Ashworth and Miguel Garcia and Julian Barker and Stephanie Thomas",

year = "2021",

month = sep,

day = "20",

language = "English",

journal = "Journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Co. Ltd",

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TY - JOUR

T1 - Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.

AU - Monk, Edward JM

AU - Rautemaa-Richardson , Riina

AU - Felton, Timothy

AU - Montalti, Alice

AU - Parkes, Matthew

AU - Templeton, Richard

AU - Ashworth, Alan

AU - Garcia, Miguel

AU - Barker, Julian

AU - Thomas, Stephanie

PY - 2021/9/20

Y1 - 2021/9/20

N2 - This single-centre retrospective study reports the dynamics of Candida bloodstream infection (CBSI) incidence in 145 patients receiving venovenous ECMO for respiratory support, between January 2014 and December 2018. Incidence rate and odds ratio (OR) of CBSI were calculated, stratified by week of ECMO exposure. Weekly incidence increased throughout the ECMO run, with a rising trend in OR (P = 0.005), and a window of continued risk after decannulation was observed. Of the 13 patients that developed CBSI, five (38%) received empirical micafungin treatment before positive culture due to clinical suspicion. Prospective studies, aiming to improve ECMO diagnostic stewardship practices and discourage antifungal prophylaxis or empiric management where unnecessary, are needed.

AB - This single-centre retrospective study reports the dynamics of Candida bloodstream infection (CBSI) incidence in 145 patients receiving venovenous ECMO for respiratory support, between January 2014 and December 2018. Incidence rate and odds ratio (OR) of CBSI were calculated, stratified by week of ECMO exposure. Weekly incidence increased throughout the ECMO run, with a rising trend in OR (P = 0.005), and a window of continued risk after decannulation was observed. Of the 13 patients that developed CBSI, five (38%) received empirical micafungin treatment before positive culture due to clinical suspicion. Prospective studies, aiming to improve ECMO diagnostic stewardship practices and discourage antifungal prophylaxis or empiric management where unnecessary, are needed.

M3 - Article

SN - 0195-6701

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

ER -

Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.

Abstract

Embargoed Document

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Projects

MFIG: Manchester Fungal Infection Group (MFIG)

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