Candidate genes for COPD in two large data sets

P. S. Bakke; G. Zhu; A. Gulsvik; X. Kong; A. G N Agusti; P. M A Calverley; C. F. Donner; R. D. Levy; B. J. Make; P. D. Paré; S. I. Rennard; J. Vestbo; E. F M Wouters; W. Anderson; D. A. Lomas; E. K. Silverman; S. G. Pillai

doi:10.1183/09031936.00091709

Candidate genes for COPD in two large data sets

P. S. Bakke, G. Zhu, A. Gulsvik, X. Kong, A. G N Agusti, P. M A Calverley, C. F. Donner, R. D. Levy, B. J. Make, P. D. Paré, S. I. Rennard, J. Vestbo, E. F M Wouters, W. Anderson, D. A. Lomas, E. K. Silverman, S. G. Pillai

Research output: Contribution to journal › Article › peer-review

Abstract

Lack of reproducibility of findings has been a criticism of genetic association studies on complex diseases, such as chronic obstructive pulmonary disease (COPD). We selected 257 polymorphisms of 16 genes with reported or potential relationships to COPD and genotyped these variants in a case-control study that included 953 COPD cases and 956 control subjects. We explored the association of these polymorphisms to three COPD phenotypes: a COPD binary phenotype and two quantitative traits (post-bronchodilator forced expiratory volume in 1 s (FEV1) % predicted and FEV1/forced vital capacity (FVC)). The polymorphisms significantly associated to these phenotypes in this first study were tested in a second, family-based study that included 635 pedigrees with 1,910 individuals. Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p

Original language	English
Pages (from-to)	255-263
Number of pages	8
Journal	European Respiratory Journal
Volume	37
Issue number	2
DOIs	https://doi.org/10.1183/09031936.00091709
Publication status	Published - 1 Feb 2011

Keywords

Chronic obstructive pulmonary disease
Genetic association
Replication
Smoking

Access to Document

10.1183/09031936.00091709

http://erj.ersjournals.com/content/37/2/255.full.pdf+html

Cite this

Bakke, P. S., Zhu, G., Gulsvik, A., Kong, X., Agusti, A. G. N., Calverley, P. M. A., Donner, C. F., Levy, R. D., Make, B. J., Paré, P. D., Rennard, S. I., Vestbo, J., Wouters, E. F. M., Anderson, W., Lomas, D. A., Silverman, E. K., & Pillai, S. G. (2011). Candidate genes for COPD in two large data sets. European Respiratory Journal, 37(2), 255-263. https://doi.org/10.1183/09031936.00091709

@article{41620edec22246a7a0db3bdf70659a2f,

title = "Candidate genes for COPD in two large data sets",

abstract = "Lack of reproducibility of findings has been a criticism of genetic association studies on complex diseases, such as chronic obstructive pulmonary disease (COPD). We selected 257 polymorphisms of 16 genes with reported or potential relationships to COPD and genotyped these variants in a case-control study that included 953 COPD cases and 956 control subjects. We explored the association of these polymorphisms to three COPD phenotypes: a COPD binary phenotype and two quantitative traits (post-bronchodilator forced expiratory volume in 1 s (FEV1) % predicted and FEV1/forced vital capacity (FVC)). The polymorphisms significantly associated to these phenotypes in this first study were tested in a second, family-based study that included 635 pedigrees with 1,910 individuals. Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p",

keywords = "Chronic obstructive pulmonary disease, Genetic association, Replication, Smoking",

author = "Bakke, {P. S.} and G. Zhu and A. Gulsvik and X. Kong and Agusti, {A. G N} and Calverley, {P. M A} and Donner, {C. F.} and Levy, {R. D.} and Make, {B. J.} and Par{\'e}, {P. D.} and Rennard, {S. I.} and J. Vestbo and Wouters, {E. F M} and W. Anderson and Lomas, {D. A.} and Silverman, {E. K.} and Pillai, {S. G.}",

year = "2011",

month = feb,

day = "1",

doi = "10.1183/09031936.00091709",

language = "English",

volume = "37",

pages = "255--263",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "2",

}

TY - JOUR

T1 - Candidate genes for COPD in two large data sets

AU - Bakke, P. S.

AU - Zhu, G.

AU - Gulsvik, A.

AU - Kong, X.

AU - Agusti, A. G N

AU - Calverley, P. M A

AU - Donner, C. F.

AU - Levy, R. D.

AU - Make, B. J.

AU - Paré, P. D.

AU - Rennard, S. I.

AU - Vestbo, J.

AU - Wouters, E. F M

AU - Anderson, W.

AU - Lomas, D. A.

AU - Silverman, E. K.

AU - Pillai, S. G.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Lack of reproducibility of findings has been a criticism of genetic association studies on complex diseases, such as chronic obstructive pulmonary disease (COPD). We selected 257 polymorphisms of 16 genes with reported or potential relationships to COPD and genotyped these variants in a case-control study that included 953 COPD cases and 956 control subjects. We explored the association of these polymorphisms to three COPD phenotypes: a COPD binary phenotype and two quantitative traits (post-bronchodilator forced expiratory volume in 1 s (FEV1) % predicted and FEV1/forced vital capacity (FVC)). The polymorphisms significantly associated to these phenotypes in this first study were tested in a second, family-based study that included 635 pedigrees with 1,910 individuals. Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p

AB - Lack of reproducibility of findings has been a criticism of genetic association studies on complex diseases, such as chronic obstructive pulmonary disease (COPD). We selected 257 polymorphisms of 16 genes with reported or potential relationships to COPD and genotyped these variants in a case-control study that included 953 COPD cases and 956 control subjects. We explored the association of these polymorphisms to three COPD phenotypes: a COPD binary phenotype and two quantitative traits (post-bronchodilator forced expiratory volume in 1 s (FEV1) % predicted and FEV1/forced vital capacity (FVC)). The polymorphisms significantly associated to these phenotypes in this first study were tested in a second, family-based study that included 635 pedigrees with 1,910 individuals. Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p

KW - Chronic obstructive pulmonary disease

KW - Genetic association

KW - Replication

KW - Smoking

U2 - 10.1183/09031936.00091709

DO - 10.1183/09031936.00091709

M3 - Article

C2 - 20562129

SN - 0903-1936

VL - 37

SP - 255

EP - 263

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 2

ER -

Candidate genes for COPD in two large data sets

Abstract

Keywords

Access to Document

Fingerprint

Cite this