Canine DLA diversity: 1. New alleles and haplotypes

L. J. Kennedy; A. Barnes; A. Short; J. J. Brown; S. Lester; J. Seddon; L. Fleeman; O. Francino; M. Brkljacic; S. Knyazev; G. M. Happ; W. E R Ollier

doi:10.1111/j.1399-0039.2006.00779.x

Canine DLA diversity: 1. New alleles and haplotypes

L. J. Kennedy, A. Barnes, A. Short, J. J. Brown, S. Lester, J. Seddon, L. Fleeman, O. Francino, M. Brkljacic, S. Knyazev, G. M. Happ, W. E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this component was to establish the range of DLA diversity in as many dog breeds as possible. In particular, we wanted to collect breeds that had not previously been studied. Data were submitted of 937 dogs of over 80 different breeds, and these included 17 'new' breeds. Twenty-eight new alleles were identified including 21 DLA-DRB1, 2 DLA-DQA1 and 5 DLA-DQB1 alleles. These occurred in many new haplotype combinations. One haplotype was identified that appeared to lack DQB1. Two other haplotypes carry two DQB1 genes. It was clear that each dog breed has a restricted range of DLA alleles and haplotypes, and no breed had all 88 haplotypes identified in this study. © 2007 Blackwell Munksgaard.

Original language	English
Pages (from-to)	272-288
Number of pages	16
Journal	Tissue Antigens
Volume	69
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0039.2006.00779.x
Publication status	Published - Apr 2007

Keywords

Alleles
DLA
Dog
Haplotypes

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10.1111/j.1399-0039.2006.00779.x

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title = "Canine DLA diversity: 1. New alleles and haplotypes",

abstract = "The aim of this component was to establish the range of DLA diversity in as many dog breeds as possible. In particular, we wanted to collect breeds that had not previously been studied. Data were submitted of 937 dogs of over 80 different breeds, and these included 17 'new' breeds. Twenty-eight new alleles were identified including 21 DLA-DRB1, 2 DLA-DQA1 and 5 DLA-DQB1 alleles. These occurred in many new haplotype combinations. One haplotype was identified that appeared to lack DQB1. Two other haplotypes carry two DQB1 genes. It was clear that each dog breed has a restricted range of DLA alleles and haplotypes, and no breed had all 88 haplotypes identified in this study. {\textcopyright} 2007 Blackwell Munksgaard.",

keywords = "Alleles, DLA, Dog, Haplotypes",

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year = "2007",

month = apr,

doi = "10.1111/j.1399-0039.2006.00779.x",

language = "English",

volume = "69",

pages = "272--288",

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T1 - Canine DLA diversity: 1. New alleles and haplotypes

AU - Kennedy, L. J.

AU - Barnes, A.

AU - Short, A.

AU - Brown, J. J.

AU - Lester, S.

AU - Seddon, J.

AU - Fleeman, L.

AU - Francino, O.

AU - Brkljacic, M.

AU - Knyazev, S.

AU - Happ, G. M.

AU - Ollier, W. E R

PY - 2007/4

Y1 - 2007/4

N2 - The aim of this component was to establish the range of DLA diversity in as many dog breeds as possible. In particular, we wanted to collect breeds that had not previously been studied. Data were submitted of 937 dogs of over 80 different breeds, and these included 17 'new' breeds. Twenty-eight new alleles were identified including 21 DLA-DRB1, 2 DLA-DQA1 and 5 DLA-DQB1 alleles. These occurred in many new haplotype combinations. One haplotype was identified that appeared to lack DQB1. Two other haplotypes carry two DQB1 genes. It was clear that each dog breed has a restricted range of DLA alleles and haplotypes, and no breed had all 88 haplotypes identified in this study. © 2007 Blackwell Munksgaard.

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KW - Alleles

KW - DLA

KW - Dog

KW - Haplotypes

U2 - 10.1111/j.1399-0039.2006.00779.x

DO - 10.1111/j.1399-0039.2006.00779.x

M3 - Article

SN - 0001-2815

VL - 69

SP - 272

EP - 288

JO - Tissue Antigens

JF - Tissue Antigens

IS - 1

ER -

Canine DLA diversity: 1. New alleles and haplotypes

Abstract

Keywords

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