TY - JOUR
T1 - Carcinoid tumors of the duodenum and the ampulla of Vater
T2 - current diagnostic and therapeutic approach in a series of 8 patients. Case series
AU - Nikou, George C
AU - Toubanakis, Christos
AU - Moulakakis, Konstantinos G
AU - Pavlatos, Spiridon
AU - Kosmidis, Christos
AU - Mallas, Elias
AU - Safioleas, Panayiotis
AU - Sakorafas, George H
AU - Safioleas, Michael C
N1 - Copyright © 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - AIM: To describe the specific characteristics of duodenal/perivaterian carcinoids and to analyze the diagnostic/therapeutic approach.MATERIAL AND METHODS: Eight patients were included in our study. Symptoms on admission included dyspepsia, upper gastrointestinal (GI) bleeding and anemia. All patients underwent upper GI endoscopy and gastrointestinal peptides (gastrin) and neuroendocrine markers (Chromogranin-A, CgA) measurement. Imaging studies were performed in all patients, including OCTREOSCAN, while in patients with ACs MRCP or ERCP was also performed, when necessary. Definite diagnosis was confirmed by histopathologic examination.RESULTS: Polypoid masses (carcinoids) were revealed at duodenal bulb and ampulla of Vater, in 5 and 3 patients, respectively. Serum gastrin was moderately increased in 4 patients, while in one patient it was more than 1000 pg/ml. Serum CgA was moderately increased in one patient, in whom OCTREOSCAN detected a solitary hepatic metastasis. Two patients with DC, of less than 1 cm of diameter, were treated by endoscopic polypectomy, while all the other patients underwent surgery. The patient with hepatic metastasis and positive OCTREOSCAN received also Octreotide LAR, resulting in stabilization of disease. No recurrence or metastases were observed during follow-up (range : 1.5-9.6 years).CONCLUSIONS: In DC tumors <1 cm endoscopic excision with close follow-up is an adequate treatment, while in tumors >1 cm and in AC, surgical resection is the treatment of choice. In metastatic tumors, resection of the primary lesion with administration of somatostatin analogues may stabilize the disease and improve patient's quality of life.
AB - AIM: To describe the specific characteristics of duodenal/perivaterian carcinoids and to analyze the diagnostic/therapeutic approach.MATERIAL AND METHODS: Eight patients were included in our study. Symptoms on admission included dyspepsia, upper gastrointestinal (GI) bleeding and anemia. All patients underwent upper GI endoscopy and gastrointestinal peptides (gastrin) and neuroendocrine markers (Chromogranin-A, CgA) measurement. Imaging studies were performed in all patients, including OCTREOSCAN, while in patients with ACs MRCP or ERCP was also performed, when necessary. Definite diagnosis was confirmed by histopathologic examination.RESULTS: Polypoid masses (carcinoids) were revealed at duodenal bulb and ampulla of Vater, in 5 and 3 patients, respectively. Serum gastrin was moderately increased in 4 patients, while in one patient it was more than 1000 pg/ml. Serum CgA was moderately increased in one patient, in whom OCTREOSCAN detected a solitary hepatic metastasis. Two patients with DC, of less than 1 cm of diameter, were treated by endoscopic polypectomy, while all the other patients underwent surgery. The patient with hepatic metastasis and positive OCTREOSCAN received also Octreotide LAR, resulting in stabilization of disease. No recurrence or metastases were observed during follow-up (range : 1.5-9.6 years).CONCLUSIONS: In DC tumors <1 cm endoscopic excision with close follow-up is an adequate treatment, while in tumors >1 cm and in AC, surgical resection is the treatment of choice. In metastatic tumors, resection of the primary lesion with administration of somatostatin analogues may stabilize the disease and improve patient's quality of life.
KW - Adult
KW - Aged
KW - Ampulla of Vater
KW - Carcinoid Tumor/diagnosis
KW - Common Bile Duct Neoplasms/diagnosis
KW - Duodenal Neoplasms/diagnosis
KW - Female
KW - Humans
KW - Liver Neoplasms/diagnosis
KW - Male
KW - Middle Aged
U2 - 10.1016/j.ijsu.2010.12.003
DO - 10.1016/j.ijsu.2010.12.003
M3 - Article
C2 - 21215338
SN - 1743-9191
VL - 9
SP - 248
EP - 253
JO - International journal of surgery (London, England)
JF - International journal of surgery (London, England)
IS - 3
ER -