Cardiac adrenergic nerve function and microvascular dysfunction in patients with cardiac syndrome X

Bernard Keavney; A. D. Monaco; I. Bruno; A. Sestito; P. Lamendola; L. Barone; A. Bagnato; R. Nerla; C. Pisanello; A. Giordano; G. A. Lanza; F. Crea

doi:10.1136/hrt.2008.156851

Cardiac adrenergic nerve function and microvascular dysfunction in patients with cardiac syndrome X

Bernard Keavney, A. D. Monaco, I. Bruno, A. Sestito, P. Lamendola, L. Barone, A. Bagnato, R. Nerla, C. Pisanello, A. Giordano, G. A. Lanza, F. Crea

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To assess whether abnormalities in cardiac uptake of 123I-metaiodobenzylguanidine (MIBG) correlate with coronary microvascular dysfunction in patients with cardiac syndrome X (CSX). Setting: University hospital. Patients: 29 patients (aged 59 (SD 7) years, 11 men) with typical CSX and a matched group of 20 healthy subjects (aged 56 (7) years, 8 men) were studied. Interventions: Planar and single photon emission computed tomography (SPECT) MIBG myocardial scintigraphy was performed in all subjects. Coronary flow response (CFR) to adenosine and to cold pressor test (CPT) in the left anterior descending (LAD) coronary artery was assessed in all CSX patients and in 12 controls by transthoracic Doppler echocardiography. Main outcome measures: Abnormalities in cardiac MIBG scintigraphy were observed in 25 CSX patients (86.2%), but in no healthy control (p

Original language	English
Pages (from-to)	550-554
Number of pages	4
Journal	Heart
Volume	95
Issue number	7
DOIs	https://doi.org/10.1136/hrt.2008.156851
Publication status	Published - Apr 2009

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10.1136/hrt.2008.156851

http://heart.bmj.com/cgi/reprint/95/7/550

Cite this

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title = "Cardiac adrenergic nerve function and microvascular dysfunction in patients with cardiac syndrome X",

abstract = "Objective: To assess whether abnormalities in cardiac uptake of 123I-metaiodobenzylguanidine (MIBG) correlate with coronary microvascular dysfunction in patients with cardiac syndrome X (CSX). Setting: University hospital. Patients: 29 patients (aged 59 (SD 7) years, 11 men) with typical CSX and a matched group of 20 healthy subjects (aged 56 (7) years, 8 men) were studied. Interventions: Planar and single photon emission computed tomography (SPECT) MIBG myocardial scintigraphy was performed in all subjects. Coronary flow response (CFR) to adenosine and to cold pressor test (CPT) in the left anterior descending (LAD) coronary artery was assessed in all CSX patients and in 12 controls by transthoracic Doppler echocardiography. Main outcome measures: Abnormalities in cardiac MIBG scintigraphy were observed in 25 CSX patients (86.2%), but in no healthy control (p",

author = "Bernard Keavney and Monaco, {A. D.} and I. Bruno and A. Sestito and P. Lamendola and L. Barone and A. Bagnato and R. Nerla and C. Pisanello and A. Giordano and Lanza, {G. A.} and F. Crea",

note = ", British Heart Foundation, United Kingdom",

year = "2009",

month = apr,

doi = "10.1136/hrt.2008.156851",

language = "English",

volume = "95",

pages = "550--554",

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T1 - Cardiac adrenergic nerve function and microvascular dysfunction in patients with cardiac syndrome X

AU - Keavney, Bernard

AU - Monaco, A. D.

AU - Bruno, I.

AU - Sestito, A.

AU - Lamendola, P.

AU - Barone, L.

AU - Bagnato, A.

AU - Nerla, R.

AU - Pisanello, C.

AU - Giordano, A.

AU - Lanza, G. A.

AU - Crea, F.

N1 - , British Heart Foundation, United Kingdom

PY - 2009/4

Y1 - 2009/4

N2 - Objective: To assess whether abnormalities in cardiac uptake of 123I-metaiodobenzylguanidine (MIBG) correlate with coronary microvascular dysfunction in patients with cardiac syndrome X (CSX). Setting: University hospital. Patients: 29 patients (aged 59 (SD 7) years, 11 men) with typical CSX and a matched group of 20 healthy subjects (aged 56 (7) years, 8 men) were studied. Interventions: Planar and single photon emission computed tomography (SPECT) MIBG myocardial scintigraphy was performed in all subjects. Coronary flow response (CFR) to adenosine and to cold pressor test (CPT) in the left anterior descending (LAD) coronary artery was assessed in all CSX patients and in 12 controls by transthoracic Doppler echocardiography. Main outcome measures: Abnormalities in cardiac MIBG scintigraphy were observed in 25 CSX patients (86.2%), but in no healthy control (p

AB - Objective: To assess whether abnormalities in cardiac uptake of 123I-metaiodobenzylguanidine (MIBG) correlate with coronary microvascular dysfunction in patients with cardiac syndrome X (CSX). Setting: University hospital. Patients: 29 patients (aged 59 (SD 7) years, 11 men) with typical CSX and a matched group of 20 healthy subjects (aged 56 (7) years, 8 men) were studied. Interventions: Planar and single photon emission computed tomography (SPECT) MIBG myocardial scintigraphy was performed in all subjects. Coronary flow response (CFR) to adenosine and to cold pressor test (CPT) in the left anterior descending (LAD) coronary artery was assessed in all CSX patients and in 12 controls by transthoracic Doppler echocardiography. Main outcome measures: Abnormalities in cardiac MIBG scintigraphy were observed in 25 CSX patients (86.2%), but in no healthy control (p

U2 - 10.1136/hrt.2008.156851

DO - 10.1136/hrt.2008.156851

M3 - Article

C2 - 18977801

SN - 1355-6037

VL - 95

SP - 550

EP - 554

JO - Heart

JF - Heart

IS - 7

ER -

Cardiac adrenergic nerve function and microvascular dysfunction in patients with cardiac syndrome X

Abstract

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