Cardioprotection in ischemia/reperfusion injury: Spotlight on sphingosine-1-phosphate and bradykinin signalling

Emmanuel Eroume A Egom; Yunbo Ke; R. John Solaro; Ming Lei

doi:10.1016/j.pbiomolbio.2010.01.001

Cardioprotection in ischemia/reperfusion injury: Spotlight on sphingosine-1-phosphate and bradykinin signalling

Emmanuel Eroume A Egom, Yunbo Ke, R. John Solaro, Ming Lei

Research output: Contribution to journal › Article › peer-review

Abstract

Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase. © 2010.

Original language	English
Pages (from-to)	142-147
Number of pages	5
Journal	Progress in biophysics and molecular biology
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/j.pbiomolbio.2010.01.001
Publication status	Published - Sept 2010

Keywords

Cardiac ischemia
Pak1
S1P

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10.1016/j.pbiomolbio.2010.01.001

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abstract = "Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase. {\textcopyright} 2010.",

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AU - Egom, Emmanuel Eroume A

AU - Ke, Yunbo

AU - Solaro, R. John

AU - Lei, Ming

PY - 2010/9

Y1 - 2010/9

N2 - Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase. © 2010.

AB - Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase. © 2010.

KW - Cardiac ischemia

KW - Pak1

KW - S1P

U2 - 10.1016/j.pbiomolbio.2010.01.001

DO - 10.1016/j.pbiomolbio.2010.01.001

M3 - Article

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VL - 103

SP - 142

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JO - Progress in biophysics and molecular biology

JF - Progress in biophysics and molecular biology

IS - 1

ER -

Cardioprotection in ischemia/reperfusion injury: Spotlight on sphingosine-1-phosphate and bradykinin signalling

Abstract

Keywords

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