TY - JOUR
T1 - Catalyst-Driven Scaffold Diversity
T2 - Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones
AU - Liddon, John T. R.
AU - James, Michael J.
AU - Clarke, Aimee K.
AU - O'brien, Peter
AU - Taylor, Richard J. K.
AU - Unsworth, William P.
PY - 2016/4/28
Y1 - 2016/4/28
N2 - Medicinally relevant spirocyclic indolenines, carbazoles and quinolines can each be directly synthesised selectively from common indolyl ynone starting materials by catalyst variation. The high yielding, divergent reactions all proceed by an initial dearomatising spirocyclisation reaction to generate an intermediate vinyl–metal species, which then rearranges selectively by careful choice of catalyst and reaction conditions.
AB - Medicinally relevant spirocyclic indolenines, carbazoles and quinolines can each be directly synthesised selectively from common indolyl ynone starting materials by catalyst variation. The high yielding, divergent reactions all proceed by an initial dearomatising spirocyclisation reaction to generate an intermediate vinyl–metal species, which then rearranges selectively by careful choice of catalyst and reaction conditions.
U2 - 10.1002/chem.201601836
DO - 10.1002/chem.201601836
M3 - Article
SN - 0947-6539
VL - 22
SP - 8777
EP - 8780
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 26
ER -