TY - JOUR
T1 - Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B
T2 - Mimicry of Monoamine Oxidase B
AU - Murray, Alexander T
AU - Dowley, Myles J H
AU - Pradaux-Caggiano, Fabienne
AU - Baldansuren, Amgalanbaatar
AU - Fielding, Alistair J
AU - Tuna, Floriana
AU - Hendon, Christopher H
AU - Walsh, Aron
AU - Lloyd-Jones, Guy C
AU - John, Matthew P
AU - Carbery, David R
N1 - © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
PY - 2015/7/27
Y1 - 2015/7/27
N2 - The flavoenzyme monoamine oxidase (MAO) regulates mammalian behavioral patterns by modulating neurotransmitters such as adrenaline and serotonin. The mechanistic basis which underpins this enzyme is far from agreed upon. Reported herein is that the combination of a synthetic flavin and alloxan generates a catalyst system which facilitates biomimetic amine oxidation. Mechanistic and electron paramagnetic (EPR) spectroscopic data supports the conclusion that the reaction proceeds through a radical manifold. This data provides the first example of a biorelevant synthetic model for monoamine oxidase B activity.
AB - The flavoenzyme monoamine oxidase (MAO) regulates mammalian behavioral patterns by modulating neurotransmitters such as adrenaline and serotonin. The mechanistic basis which underpins this enzyme is far from agreed upon. Reported herein is that the combination of a synthetic flavin and alloxan generates a catalyst system which facilitates biomimetic amine oxidation. Mechanistic and electron paramagnetic (EPR) spectroscopic data supports the conclusion that the reaction proceeds through a radical manifold. This data provides the first example of a biorelevant synthetic model for monoamine oxidase B activity.
U2 - 10.1002/anie.201503654
DO - 10.1002/anie.201503654
M3 - Article
C2 - 26087676
SN - 1433-7851
VL - 54
SP - 8997
EP - 9000
JO - Angewandte Chemie (International ed. in English)
JF - Angewandte Chemie (International ed. in English)
IS - 31
ER -