@article{f3e3fb0e37fb40629e4f001bb6eff57b,
title = "Catalytic Asymmetric γ-Lactam Synthesis from Enolisable Anhydrides and Imines",
abstract = "An anion-binding approach to the problem of preparing enantioenriched γ-lactams from enolisable anhydrides and imines is reported. A simple bisurea catalyst promotes the cycloaddition between α-aryl succinic anhydrides and either PMP- or benzhydryl-protected aldimines to provide γ-lactams with two contiguous stereocentres (one quaternary) with complete diastereocontrol and high to excellent enantioselectivity for the first time. A DFT study has provided insight into the catalyst mode of action and the origins of the observed stereocontrol.",
keywords = "cyclic anhydrides, cycloadditions, DFT, imines, lactams",
author = "Collar, {Aar{\'o}n Guti{\'e}rrez} and Cristina Trujillo and Bruce Lockett-Walters and Brendan Twamley and Connon, {Stephen J.}",
note = "Funding Information: This publication has emanated from research supported by the Science Foundation Ireland (SFI-12-IA-1645). We are grateful to the Irish Centre for High-End Computing (ICHEC) for the provision of computational facilities. We are indebted to Dr. Goar S#nchez from ICHEC for the AIM graphical outputs. Funding Information: This publication has emanated from research supported by the Science Foundation Ireland (SFI-12-IA-1645). We are grateful to the Irish Centre for High-End Computing (ICHEC) for the provision of computational facilities. We are indebted to Dr. Goar S?nchez from ICHEC for the AIM graphical outputs. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = may,
day = "28",
doi = "10.1002/chem.201901028",
language = "English",
volume = "25",
pages = "7275--7279",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "John Wiley & Sons Ltd",
number = "30",
}